Clincal and Translational Science Award

美国国立卫生研究院临床和转化科学奖RFA促进了学术医疗机构的努力，以消除将基本发现转化为改善我国公民健康的障碍，并纠正临床和转化劳动力的短缺问题。东南威斯康星临床与转化科学研究所的这一建议是根据该地区生物医学企业的需求和资源量身定制的，并提供了一个新颖的变革性计划来实现上述目标。基于我们地区主要学术和医疗机构之间的长期合作历史，我们建立了一个独特的学术社区合作伙伴关系，包括威斯康星医学院、威斯康星大学密尔沃基分校、马凯特大学、密尔沃基工程学院、Froedtert医院、威斯康星儿童医院、Zablocki VA医疗中心和威斯康星血液中心。背景设置在一个具有显著的种族和社会多样性的大型城市社区。我们的建议汇集了伙伴机构的各种资源，以确定和解决阻碍该地区开展临床和转化研究的障碍。CTSI的转型环境着重于我们的研究团队之间的相互依存和相互关系，以及关键职能与CTSA其他部门在整合、促进和影响角色方面的关系。

The National institutes of Health's RFA for Clinical and Translational Science Awards has catalyzed the efforts of academic medical institutions to remove impediments to the translation of fundamental discoveries into better health for our citizens and rectify shortages within the clinical and translational workforce. This proposal of the Clinical and Translational Science Institute of Southeast Wisconsin is tailored to the needs and resources of the biomedical enterprise in the region and offers a novel and transformative plan to achieve the above mentioned goals. Building on the long collaborative history among the major academic and healthcare institutions in our area, we have constructed a unique academic-community partnership comprised of the Medical College of Wisconsin, University of Wisconsin-Milwaukee, Marquette University, Milwaukee School of Engineering, Froedtert Hospital, Children's Hospital of Wisconsin, Zablocki VA Medical Center and BloodCenter of Wisconsin, set in the milieu of a large urban community with remarkable ethnic and social diversity. Our proposal brings together the various resources of the partner institutions to identify and address the obstacles that impede the conduct of clinical and translational research in the region. The transforming environment of our CTSI focuses on the interdependency and interrelationship of our research teams and the relationship of the key functions to the rest of the CTSA in their integrating, enabling and effecting roles. To accomplish this transformation, we propose (and have begun to implement during the pre-award years) 1) To develop a distinct "Academic Home" for the discipline of clinical and translational science - the Clinical and Translational Science Institute (CTSI) - which transcends intra-and inter-institutional barrier, empowers experienced leadership to have the authority and resources to promote, facilitate, coordinate and foster the continuum of translational research from bench to bedside (T1), to clinical practices (T2), and to our communities (T3); 2) To increase the number of investigators participating in clinical research through innovative programs within the CTSI; 3) To develop, align, and coordinate infrastructure across institutions to provide our scientists with the resources required for Clinical and Translational research; and 4) To engage clinical practices and the community in research h that enhances public health. Our Community Engagement program is an MCW strength. We will build on an existing network of the Healthier Wisconsin Partnership Program (HWPP) and expertise and resources of our partners in medical, biomedical engineering, dentistry, nursing, social sciences and allied health disiciplines to implement novel community based (T3) research programs. We believe our CTSA model is transferable to other similarly-sized academic research communities across the country.