CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 基础设施走向这一领域的研究，而不是直接提供资金， 向子项目或子项目工作人员提供NCRR补助金。 国家卫生研究院的临床和转化科学奖RFA促进了学术医疗机构的努力，以消除将基本发现转化为更好的健康的障碍，并纠正临床和转化劳动力的短缺。东南威斯康星州临床和转化科学研究所的这一建议是针对该地区生物医学企业的需求和资源而量身定制的，并提供了一个新颖的变革计划来实现上述目标。在我们地区主要学术和医疗机构之间的长期合作历史的基础上，我们建立了一个独特的学术社区合作伙伴关系，包括威斯康星州医学院，威斯康星大学密尔沃基分校，马奎特大学，密尔沃基工程学院，Froedtert医院，威斯康星州儿童医院，Zablocki VA医疗中心和威斯康星州血液中心，故事发生在一个具有显著种族和社会多样性的大型城市社区的环境中。我们的建议汇集了合作机构的各种资源，以确定和解决阻碍该地区开展临床和转化研究的障碍。我们的CTSI的转型环境侧重于我们的研究团队的相互依赖和相互关系，以及关键职能与CTSA其他部门在整合，使能和影响角色方面的关系。为了实现这一转变，我们建议（并已开始在获奖前几年实施）1）为临床和转化科学学科建立一个独特的“学术之家”-临床和转化科学研究所（CTSI）-超越机构内和机构间的障碍，赋予经验丰富的领导权力和资源，以促进，促进，协调和促进从实验室到床边（T1），临床实践（T2）和我们的社区（T3）的转化研究的连续性; 2）通过CTSI内的创新计划增加参与临床研究的研究人员数量; 3）开发，调整和协调跨机构的基础设施，为我们的科学家提供临床和转化研究所需的资源;和4）让临床实践和社区参与增强公共卫生的研究。我们的社区参与计划是MCW的优势。我们将建立在现有的网络更健康的威斯康星州合作伙伴计划（HWPP）和专业知识和资源，我们的合作伙伴在医学，生物医学工程，牙科，护理，社会科学和联合健康disciplines实施新的社区为基础的（T3）研究计划。我们相信我们的CTSA模式可以转移到全国其他类似规模的学术研究社区。相关性（参见说明）：迫切需要更好的预防措施、更准确的诊断和更有效的治疗，以改善我们公民的健康。该应用程序提供了一种新颖而全面的机制，通过研究和教育来满足这些需求。它在威斯康星州东南部创造了一个无国界的协作环境，供生物医学研究人员、医疗保健提供者、教育工作者、公民和行业协同合作，将基本发现转化为我们公民更好的健康。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The National institutes of Health's RFA for Clinical and Translational Science Awards has catalyzed the efforts of academic medical institutions to remove impediments to the translation of fundamental discoveries into better health for our citizens and rectify shortages within the clinical and translational workforce. This proposal of the Clinical and Translational Science Institute of Southeast Wisconsin is tailored to the needs and resources of the biomedical enterprise in the region and offers a novel and transformative plan to achieve the above mentioned goals. Building on the long collaborative history among the major academic and healthcare institutions in our area, we have constructed a unique academic-community partnership comprised of the Medical College of Wisconsin, University of Wisconsin-Milwaukee, Marquette University, Milwaukee School of Engineering, Froedtert Hospital, Children's Hospital of Wisconsin, Zablocki VA Medical Center and BloodCenter of Wisconsin, set in the milieu of a large urban community with remarkable ethnic and social diversity. Our proposal brings together the various resources of the partner institutions to identify and address the obstacles that impede the conduct of clinical and translational research in the region. The transfonning environment of our CTSI focuses on the interdependency and interrelationship of our research teams and the relationship of the key functions to the rest of the CTSA in their integrating, enabling and effecting roles. To accomplish this transfonnation, we propose (and have begun to implement during the pre-award years) 1) To develop a distinct "Academic Home" for the discipline of clinical and translational science - the Clinical and Translational Science Institute (CTSI) - which transcends intra-and inter-institutional barrier, empowers experienced leadership to have the authority and resources to promote, facilitate, coordinate and foster the continuum of translational research from bench to bedside (Tl), to clinical practices (T2), and to our communities (T3); 2) To increase the number of investigators participating in clinical research through innovative programs within the CTSI; 3) To develop, align, and coordinate infrastructure across institutions to provide our scientists with the resources required for Clinical and Translational research; and 4) To engage clinical practices and the community in research h that enhances public health. Our Community Engagement program is an MCW strength. We will build on an existing network of the Healthier Wisconsin Partnership Program (HWPP) and expertise and resources of our partners in medical, biomedical engineering, dentistry, nursing, social sciences and allied health disiciplines to implement novel community based (T3) research programs. We believe our CTSA model is transferable to other similarly-sized academic research communities across the country. RELEVANCE (See instructions): Better preventive measures, more accurate diagnostics, and more effective therapies are badly needed to improve the health of our citizens. This application provides a novel and comprehensive mechanism to address these needs through research and education. It creates a borderless, collaborative environment in SE Wisconsin for biomedical researchers, healthcare providers, educators, citizens, and industry to work together synergistically and translate the fundamental discoveries into better health for our citizens.