CLINCAL AND TRANSLATIONAL SCIENCE AWARD

临床和转化科学奖

• 批准号: 8365157
• 负责人: REZA NONE SHAKER
• 金额: $ 303.87万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365157
• 关键词: Award; Translational Research

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The National institutes of Health's RFA for Clinical and Translational Science Awards has catalyzed the efforts of academic medical institutions to remove impediments to the translation of fundamental discoveries into better health for our citizens and rectify shortages within the clinical and translational workforce. This proposal of the Clinical and Translational Science Institute of Southeast Wisconsin is tailored to the needs and resources of the biomedical enterprise in the region and offers a novel and transformative plan to achieve the above mentioned goals. Building on the long collaborative history among the major academic and healthcare institutions in our area, we have constructed a unique academic-community partnership comprised of the Medical College of Wisconsin, University of Wisconsin-Milwaukee, Marquette University, Milwaukee School of Engineering, Froedtert Hospital, Children's Hospital of Wisconsin, Zablocki VA Medical Center and BloodCenter of Wisconsin, set in the milieu of a large urban community with remarkable ethnic and social diversity. Our proposal brings together the various resources of the partner institutions to identify and address the obstacles that impede the conduct of clinical and translational research in the region. The transfonning environment of our CTSI focuses on the interdependency and interrelationship of our research teams and the relationship of the key functions to the rest of the CTSA in their integrating, enabling and effecting roles. To accomplish this transfonnation, we propose (and have begun to implement during the pre-award years) 1) To develop a distinct "Academic Home" for the discipline of clinical and translational science - the Clinical and Translational Science Institute (CTSI) - which transcends intra-and inter-institutional barrier, empowers experienced leadership to have the authority and resources to promote, facilitate, coordinate and foster the continuum of translational research from bench to bedside (Tl), to clinical practices (T2), and to our communities (T3); 2) To increase the number of investigators participating in clinical research through innovative programs within the CTSI; 3) To develop, align, and coordinate infrastructure across institutions to provide our scientists with the resources required for Clinical and Translational research; and 4) To engage clinical practices and the community in research h that enhances public health. Our Community Engagement program is an MCW strength. We will build on an existing network of the Healthier Wisconsin Partnership Program (HWPP) and expertise and resources of our partners in medical, biomedical engineering, dentistry, nursing, social sciences and allied health disiciplines to implement novel community based (T3) research programs. We believe our CTSA model is transferable to other similarly-sized academic research communities across the country. RELEVANCE (See instructions): Better preventive measures, more accurate diagnostics, and more effective therapies are badly needed to improve the health of our citizens. This application provides a novel and comprehensive mechanism to address these needs through research and education. It creates a borderless, collaborative environment in SE Wisconsin for biomedical researchers, healthcare providers, educators, citizens, and industry to work together synergistically and translate the fundamental discoveries into better health for our citizens.

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 国家卫生研究院的临床和翻译科学奖RFA促进了学术医疗机构的努力，消除了将基本发现转化为更好的公民健康的障碍，并纠正了临床和翻译劳动力的短缺。威斯康星州东南部的临床和转化科学研究所的这项建议是根据该地区生物医药企业的需求和资源量身定做的，并为实现上述目标提供了一个新颖的变革性计划。在我们地区主要学术和医疗机构长期合作的基础上，我们建立了独特的学术-社区合作伙伴关系，包括威斯康星州医学院、威斯康星大学密尔沃基分校、马奎特大学、密尔沃基工程学院、弗罗德特医院、威斯康星州儿童医院、Zablocki VA医学中心和威斯康星州血统中心，位于一个具有显著种族和社会多样性的大型城市社区的环境中。我们的建议汇集了合作机构的各种资源，以确定和解决阻碍该地区开展临床和转化性研究的障碍。我们CTSI的转型环境侧重于我们研究团队的相互依存和相互关系，以及关键职能与CTSA其他部门在整合、支持和发挥作用方面的关系。为了实现这一转变，我们建议(并已在颁奖前几年开始实施)1)为临床和翻译科学学科发展一个独特的“学术之家”-临床和翻译科学研究所(CTSI)-它超越机构内和机构间的障碍，授权经验丰富的领导者拥有权威和资源，以促进、促进、协调和促进从长凳到床边(TL)、到临床实践(T2)和我们的社区(T3)的翻译研究的连续性；2)通过CTSI内的创新计划，增加参与临床研究的研究人员的数量；3)开发、调整和协调各机构的基础设施，为我们的科学家提供临床和转译研究所需的资源；以及4)让临床实践和社区参与到提高公共健康的研究中来。我们的社区参与计划是MCW的强项。我们将在威斯康星州健康伙伴计划(HWPP)的现有网络以及我们在医疗、生物医学工程、牙科、护理、社会科学和相关健康学科的合作伙伴的专业知识和资源的基础上，实施新的基于社区的(T3)研究计划。我们相信，我们的CTSA模式可以推广到全国其他类似规模的学术研究社区。相关性(见说明)：迫切需要更好的预防措施、更准确的诊断和更有效的治疗来改善我国公民的健康。这一应用程序提供了一种新颖而全面的机制，通过研究和教育来满足这些需求。它在威斯康星州东南部创造了一个无边界的协作环境，让生物医学研究人员、医疗保健提供者、教育工作者、公民和行业协同合作，将基本发现转化为我们公民更好的健康。