Los Angeles Basin Clinical and Translational Science Institute

临床和转化科学奖（CTSA）的修订申请将支持洛杉矶盆地临床和转化科学研究所（CTSI）的持续发展。我们的愿景是改善洛杉矶城市多样化和服务不足人口的健康，并在此过程中获得知识，我们可以与他人分享，以改善全球城市环境和特大城市的健康。为了实现这一愿景，我们在洛杉矶市中心与领先的学术、临床和社区卫生组织建立了独特的伙伴关系。我们正在将这一伙伴关系转变为一个卓越的临床和转化科学研究所，专注于为不同的城市社区提供更好的健康。我们为CTSI确立了四个主要目标：建立在许多独立优势的基础上，创建一个综合的学术基地，高度重视临床和转化科学；创建新的转化研究团队并开展项目，利用我们独特的人口和伙伴关系来解决我们当地社区的最佳科学机会和最重要的卫生优先事项；改革教育和培训，培养以临床和转化研究为主要职业的骨干人才；实施和传播我们所学到的知识，以改善当地社区的健康状况，并通过区域和国家网络与合作推进转化研究。为了实现这些目标，我们组建了一个卓越的领导团队，通过CTSI创建：为积极开发新研究项目和团队提供优秀资源，为促进和支持基础、临床和社区研究提供强大的基础设施，为数据采集、整合、管理和分析提供尖端方法；利用远程教育对基础、临床和社区研究人员进行综合培训，并注重对不同社区的研究；一种利用专业传播专业知识传播我们研究结果的新方法；还有一个专业的评估小组来跟踪和评估我们的进展和影响。利用330万美元的机构支持，我们已经在将当地环境转变为高度重视临床和转化研究的家园方面取得了重大进展。我们展示了强大的能力来产生和支持令人兴奋的新研究，从长凳到我们的社区。有了CTSA和在五年内承诺的1870万美元的机构支持，我们将扩大到一个功能齐全的研究所，这将对改善城市健康和推进临床和转化研究学科产生重大影响。

This revised application for a Clinical and Translational Science Award (CTSA) would support the continued development of the Los Angeles Basin Clinical and Translational Science Institute (CTSI). Our vision is to improve health of the diverse and underserved population of urban Los Angeles and, in doing so, to gain knowledge that we can share with others to improve health in urban settings and megacities across the globe. In pursuit of that vision, we have established a unique partnership of leading academic, clinical and community health organizations in the urban heart of Los Angeles. We are transforming this partnership into a preeminent clinical and translational science institute focused on better heath for diverse, urban communities. We have established four main goals for the CTSI: build on many independent strengths to create an integrated academic home that places high priority on clinical and translational science; create new translational research teams and conduct projects that leverage our unique populations and partnerships to address the best scientific opportunities and most important health priorities of our local communities; transform education and training to create a cadre of people with a major career focus on clinical and translational research; and implement and disseminate what we learn to improve health in our local communities and advance translational research through regional and national networks and collaborations. To achieve these goals, we have assembled an exceptional leadership team that is creating through the CTSI: outstanding resources for active development of new research projects and teams, a robust infrastructure to promote and support basic, clinical and community research, cutting edge methodologies for data acquisition, integration, management and analysis; integrated training of basic, clinical and community researchers using distance education and a focus on research for the diverse communities; a novel approach to dissemination of our findings using professional communications expertise; and a professional evaluation group to track and evaluate our progress and impact. Using $3.3M of institutional support, we have already made significant progress in transforming our local environment to a home that highly values clinical and translational research. We demonstrate strong ability to generate and support exciting new research, from the bench to our communities. With a CTSA and a pledge of $18.7M of institutional support over five years, we will expand to a fully functional institute that will have a have a major impact to improve urban health and advance the discipline of clinical and translational research.