Biostatics

梅奥临床癌症中心的生物统计共享资源(BSR)提供了专家 与MCCC调查人员进行了超过35年的统计合作。其目的是提供统计和 为开发和开展同行评议的癌症研究而开展的生物主题合作 由MCCC调查人员。研究包括基础科学、临床试验、流行病学研究和 其他翻译和教育研究。CCSG资金的主要用途是支持统计和 在试点项目上进行生物数学合作，协助研究人员制定经批准的 没有以其他方式资助但导致外部资助的研究项目，并支持意外 在MCCC批准的项目上进行统计合作的需求。在其历史上，BSR经历了 自然和刻意的进化和扩张，受到MCCC不断扩大的研究活动的刺激。 在目前的赠款期间，BSR在两个主要领域成功地、战略性地扩大：高 维度基因组和蛋白质组数据分析(4名具有这方面专业知识的新教员)，以及所有3个MCCC 校园。BSR教员实际位于所有3个MCCC校区，并且整个资源 通过多种机制定期、有效地进行沟通，以确保协调协作。 业务流程重组将多个重点领域(团队)捆绑在一起，形成一个组织良好、高效的核心。它们是：(I) 负责癌症临床试验、相关转化性研究、介入的临床试验团队 心理社会研究、病人和公共教育研究项目，(2)人口科学小组 负责为癌症观测提供统计协作和数据管理支持 研究，包括遗传和分子流行病学，(3)生活质量小组负责提供 MCCC调查人员的一般和特定协作、测量工具和分析 临床和心理社会干预对癌症患者、家庭、照顾者和其他人的影响，以及 (4)一个生物数学小组，在成像的数学方面提供协作专门知识， 数据处理和分析，疾病过程的数学建模，以及一般的数学或 算法问题。BSR为MCCC研究人员提供统计和生物数学合作 在MCCC的所有三个校区。该资源卓有成效，有528个同行评审 在目前的赠款期间出版，并在美国国立卫生研究院或美国国立卫生研究院的104项同等赠款上进行了合作 当前授权期。

The Biostatistics Shared Resource (BSR) of the Mayo Clinic Cancer Center (MCCC) has provided expert statistical collaboration with MCCC investigators for over 35 years. The purpose is to provide statistical and biomathematical collaboration for the development and conduct of peer-reviewed cancer research generated by MCCC investigators. Research encompasses basic science, clinical trials, epidemiologic research, and other translational and educational research. The primary usage of CCSG funds is to support statistical and biomathematical collaboration on pilot projects, for assistance to investigators in developing approved research projects not otherwise funded but leading towards external funding, and to support unanticipated needs for statistical collaboration on MCCC approved projects. Over its history the BSR has undergone a natural and deliberate evolution and expansion, spurred by the expanding research activities of the MCCC. In the current grant period the BSR has successfully and strategically expanded in two primary areas: high dimensional genomic and proteomic data analysis (4 new faculty with this expertise), and to all 3 MCCC campuses. BSR faculty are physically located on all 3 MCCC campuses, and the entire resource communicates regularly and effectively through multiple mechanisms to ensure coordinated collaboration. The BSR has multiple focus areas (teams) tied together into a well-organized, efficient core. These are: (I) a Clinical Trials team responsible for cancer clinical trials, associated translational research, interventional psychosocial research, and patient and public education research projects, (II) a Population Science team responsible for providing statistical collaboration and data management support for cancer observational studies, including genetic and molecular epidemiology, (III) a Quality of Life team responsible for providing general and specific collaboration, measurement tools, and analysis for MCCC investigators investigating the impact of clinical and psychosocial interventions on cancer patients, families, caregivers, and others, and (IV) a Biomathematics team that provides collaborative expertise in the mathematical aspects of imaging, data processing and analysis, mathematical modeling of diease processes, and general mathematical or algorithmic issues. The BSR provides statistical and biomathematical collaboration to MCCC investigators across all three MCCC campuses. The resource has been remarkably productive, with 528 peer reviewed publications in the current grant period, and has collaborated on 104 NIH or NIH equivalent grants in the current grant period.