SWAN Repository III

描述（由申请人提供）：本竞争性更新申请旨在提供血清、血浆、尿液、DNA和转化细胞的SWAN储存库的持续维护和相关活动，这些储存库是在来自5个种族的3302名女性人群中进行的一项为期10年的研究中生成的，这些女性在绝经过渡之前、期间和之后每年接受一次评价。这些知识库是全国妇女健康研究（SWAN）的一个部门，旨在支持、促进和扩展核心SWAN;此外，知识库还提供了一种向更广泛的科学界开放SWAN资源的机制。实施与这一竞争性更新的三个拟议具体目标有关的活动将：1）为继续管理现有的170万份储存库标本以及2009年至2014年部署SWAN IV后将增加的标本提供条件; 2）扩大DNA库，这是最常见的标本类型，由于我们对细胞永生化的投资，它是唯一可再生的; 3）通过开发一个两级网络“数据仓库”，促进有关SWAN研究、其数据和储存库资源的有效信息交换; 4）提供标本使用申请审查过程的持续管理和标本分配的行政管理，包括材料转让协议; 5）参与促进标本使用的战略; 6）扩大与SWAN研究及其知识库相关的遗传学研究的范围。

DESCRIPTION (provided by applicant): This competing renewal application is to provide for ontinued maintenance of and activities associated with the SWAN Repositories of serum, plasma, urine, DNA and transformed cells generated from a 10-year study of a population of 3302 women from 5 ethnic groups who have been evaluated annually prior to, during and following the menopausal transition. These Repositories, an arm of the Study of Women's Health Across the Nation (SWAN), are meant to support, facilitate and extend the Core SWAN; additionally, the Repositories provide a mechanism for opening the resources of SWAN to the greater scientific community. Implementing activities associated with three proposed specific aims of this competing renewal will 1) provide for the continued management of the current 1.7 million Repository specimens and the additional specimens that will accrue as a result of fielding SWAN IV in 2009 to 2014; 2) expand the DNA Repository, the most frequently requested specimen type that is uniquely renewable because of our investment in cell immortalization; 3) promote effective information interchange about the SWAN Study, its data and the Repository resources through development of a 2-level web-based "data warehouse"; 4) provide for continued administration of the application review process for specimen utilization and administrative management of specimen distribution including Material Transfer Agreements; 5) engage in strategies to promote utilization of specimens; and, 6) expand the scope of the genetics studies associated with the SWAN study and its Repository.