RISK FACTORS FOR PROGRESSION OF OSTEOARTHRITIS OF THE KNEE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 膝关节OA的原因尚不清楚，但很可能是生物力学因素导致了受影响软骨和骨的异常负荷。有效的非手术干预是有限的，可能包括加强，锻炼和使用手杖或矫正器，但肌肉活动可能是最重要的可改变因素。本研究旨在研究年龄相关性膝关节骨关节炎患者步态过程中的肌肉力量和协调策略。这将通过MRI、步态分析、肌电图和生物力学建模和模拟的组合来完成。本项目将建立在项目4所预测的临床基础之上，该项目采用临床方法探索TKA后OA的进展。布坎南博士将担任科学导师，斯奈德-麦克勒博士将担任职业导师。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Causes of knee OA are unknown, but it is likely that biomechanical factors contribute to abnormal loading on the affected cartilage and bone. Effective non-surgical interventions are limited and may include strengthening, exercise and use of a cane or orthotic, but muscle activity may be the most significant modifiable factor. The proposed study is designed to investigate muscle forces and coordination strategies during gait in individuals with age-related osteoarthritis of the knee. This will be done thought a combination of MRI, gait analysis, electromyography, and biomechanical modeling and simulation. This project will build upon the clinical foundation projected by project #4, which takes a clinical approach to explore the progression of OA following TKA. Dr. Buchanan will serve as scientific mentor and Dr. Snyder-Mackler will be career mentor.