DRUG DISCOVERY OF PKB INHIBITORS AS ANTI-TUMOR AGENTS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们的研究努力是对小说的发现和调查 化合物作为治疗癌症的潜在药物。这个 焦点将集中在PKB(蛋白激酶B)的发现上 使用基于结构的分子模拟方法的缓蚀剂 其次是以计算化学为指导的先导优化。 在另一条途径上，新的PKB抑制剂的发现将是 从不同来源的天然产物化合物中进行搜索 与我们系内的研究项目隔绝在 查米纳德大学以及来自该校的筛选 夏威夷的各种学术研究实验室。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Our research endeavor is the discovery and investigation of novel compounds as potential drugs for the treatment of cancer. The focus will center on the discovery of PKB (Protein Kinase B) inhibitors utilizing a structure based molecular modeling approach followed by lead optimization guided by computational chemistry. In another avenue, discovery of novel PKB inhibitors will be searched from a diverse source of natural product compounds isolated from research programs within our Department at Chaminade University as well as the screening of the same from various academic research laboratories in Hawaii.