NEURO-COGNITIVE SELF-REGULATION MECHANISMS AND THEIR RELATION TOOBESITY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 达到成功体重管理干预的基准要求个人 做出艰难的选择，通常包括具有挑战性的和持续的自我控制努力。这个 拟议的研究将调查在体重管理方面苦苦挣扎的个人 表现出与注意和自我控制相关的特征性神经认知指数 因为干预往往涉及努力实现持续的生活方式改变 这些指数是否可以额外预测干预结果 这样的人。以下是要测试的问题：(1)个人是否 与体重管理作斗争表现出明显的冲动或困难，涉及 注意力转移，工作记忆，以及对其他反射性行为的抑制？做这样的事 指数与BMI和干预效果等客观指标相关 疗程？(2)体重管理问题是否伴有夸张？ 对食物暗示的情感驱动的神经反应和/或相对无法调节这种反应 回应？(3)常见的食物暗示，比如胃口的香味，通常会产生负面影响吗？ 认知控制功能？这些问题将通过使用客观和 经过验证的神经生理和行为方法。预计在该地区获得的数据 调查的初始阶段将为未来的资金和研究以及 在特拉华大学、A.I.杜邦医院和 以及特拉华州生物技术研究所的INBRE核心中心。此外，这一点 该项目将为本科生和研究生提供一个独特的培训机会 希望从事临床和神经认知研究之间的工作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Meeting benchmarks of successful weight management intervention requires that individuals make difficult choices, often involving challenging and sustained efforts of self-control. The proposed research will investigate whether individuals struggling with weight management exhibit characteristic neuro-cognitive indices related to attentional- and self-control and  because intervention often involves effortful implementation of sustained lifestyle changes  whether such indices might additionally predict intervention outcomes within a population of such individuals. The following are among the questions to be tested: (1) Do individuals struggling with weight management exhibit marked impulsiveness or difficulties involving attention shifting, working memory, and the inhibition of otherwise reflexive behaviors? Do such indices correlate with objective measures such as BMI and efficacy of intervention over the course of treatment? (2) Are weight management problems accompanied by exaggerated affectively-driven neural responses to food cues and/or by a relative inability to regulate such responses? (3) Do common food cues, such as appetitive aromas generally negatively impact cognitive control functions? These issues will be investigated through the use of objective and proven neuro-physiological and behavioral methods. It is anticipated that data obtained in the initial stages of investigation will set the stage for future funding and research, as well as for building further bridges between the University of Delaware, the A.I duPont Hospital for Children, and INBRE core centers at the Delaware Biotechnology Institute. Furthermore, this project will provide a unique training opportunity for undergraduate and graduate students wishing to work at the interface between clinical and neuro-cognitive research.