A New Method for Determining Gastric Acid Output Using a Wireless Capsule

与酸有关的疾病有很多，往往需要长期治疗和维持。其中许多疾病没有症状，因此难以诊断和治疗。胃分析是对胃酸输出量的定量测量，是诊断胃酸相关疾病和持续评估治疗反应的重要工具。目前，胃分析需要一个技术上困难的过程，通过鼻胃管进行胃抽吸，这是昂贵的，侵入性的，并且对患者来说不舒服。最近推出了SmartPill，这是一种一次性药丸，可以测量整个胃肠道的pH值、温度和压力。我们建议进行一项试点研究，以验证一种新的胃分析方法，即摄入具有已知缓冲能力的SmartPill，以测量胃中的酸度和酸输出量。我们将研究已知酸相关疾病的患者，以评估其对患者的有用性。感兴趣的受试者将报告到NIH门诊胃肠门诊进行评估。受试者在下一剂抗分泌药物之前将进行胃分析，使用胃抽吸法，然后使用SmartPill法。结果将包括胃酸相关疾病患者单位时间内胃酸输出量的定量测量，以及接受多种抗分泌药物治疗的患者的抑酸效果评估。

Acid related disorders are numerous and often require chronic treatment and maintenance. Many of these diseases are without symptoms and therefore difficult to diagnose and treat. Gastric analysis is the quantitative measurement of gastric acid output and is a critical tool for the diagnosis of acid related disorders and the ongoing assessment of therapy response. At present gastric analysis requires a technically difficult procedure, using gastric aspiration through a nasogastric tube, that is costly, invasive, and uncomfortable for patients. Recently there is introduction of the SmartPill, which is a disposable pill that measures pH, temperature, and pressure throughout the GI tract. We propose a pilot study to validate a new method of gastric analysis with the ingestion of the SmartPill with a meal of a known buffering capacity to measure both the acidity and quantity of acid output in the stomach. We will study patients with known acid related disorders to assess its usefulness in patients. Interested subjects will report to the NIH outpatient gastrointestinal clinic for evaluation. Subjects will have gastric analysis just before their next dose of anti-secretory medication using the gastric aspirate method followed by the SmartPill method. Outcomes will include a quantitative measurement of gastric acid output in unit time in patients with acid related disorders, and the assessment of acid suppression in patients treated with a variety of anti-secretory medications. We are approximately midway in our enrollment of patients in this phase of the study and therefore there are no accomplishments that can be reported at this time.