NINDS Center Core at the University of Minnesota

这是一份申请NINDS机构中心核心拨款的提案，用于支持明尼苏达大学的神经科学研究。该中心及其核心的使命是通过提供最先进的、共享的设备设施和技术和科学支持，加强神经系统的基础和转化研究。该中心汇集了一个由11名ninds资助的研究人员组成的主要小组，他们使用小鼠模型研究人类神经系统疾病/紊乱和神经系统功能。该中心还高度重视帮助新的神经科学研究人员建立他们的研究项目和nind资助的研究人员，而不需要合格的资助。在可能的情况下，该中心还向一大群研究人员提供服务和资源，其中许多是由NIH资助的，他们的研究重点是神经系统。

This is a proposal for an NINDS Institutional Center Core grant to support neuroscience research at the University of Minnesota. The mission of the Center and its Cores is to enhance basic and translational research on the nervous system by providing state-of-the art, shared equipment facilities with technical and scientific support. The Center brings together a primary group of 11 NINDS-funded investigators using mouse models to study human neurological disease/disorders and nervous system function. The Center also gives high priority to helping new neuroscience investigators establish their research programs and NINDS-funded investigators without qualifying grants. The Center also offers its services and resources when possible to a large group of investigators, many NIH funded, whose research is focused on the nervous system. The three research Cores provide technological services, training and scientific expertise to increase productivity, promote new research directions and foster collaborations among Center investigators. The Cores were selected to provide access to widely needed, even critical, tools used in the study of mouse models. These tools are best offered in a central facility in which investigators can take advantage of standardized and optimized protocols as well as expert technical assistance. The Cores were also selected to provide access to new, powerful tools for the investigation of nervous system function/dysfunction not generally available to individual investigators. By focusing on the study and evaluation of mouse models, there is a high potential for innovative synergistic effects across the Cores. The Genetic Manipulation Core provides the generation of bacterial artificial chromosome transgenic mice and viral vectors to manipulate gene expression in vitro and in vivo. The Behavioral Phenotyping Core provides facilities and technical support for the evaluation of a spectrum of motor and cognitive behaviors as well as general neurological status in the mouse. The Imaging and Tract Tracing Core provides investigators with the tools and expertise for modern imaging (single and two-photon microscopy), tract tracing/histology, and activity-dependent optical imaging. The fourth Administrative Core with the Executive Committee is responsible for Center oversight, administers the institutional sharing plan, promotes collaborations, informs the neuroscience community, seeks new technologies and evaluates the performance of the Center. The Center and Cores will increase the impact and productivity of NINDS-funded investigators, promote new research directions and foster collaborations among Center researchers.