CAREER DEVELOPMENT IN DIABETES RESEARCH FOR PEDIATRIC ENDOCRINOLOGISTS

描述(由申请者提供)：该申请旨在通过Joslin糖尿病中心和波士顿儿童医院的联合机构职业发展计划，促进多元化和训练有素的儿科内分泌学家群体进入儿科糖尿病研究领域的职业发展。通过对已获得儿科内分泌学奖学金的儿科内分泌学者进行辅导培训，该联合计划将支持和培育与1型糖尿病相关的生物医学和行为糖尿病研究方面的初级教员的职业发展。基于Joslin糖尿病中心与波士顿儿童医院长期合作的历史，我们广泛的糖尿病研究项目，以及我们在最近完成的儿科糖尿病医生K12职业发展基金的支持下，儿科内分泌学家成为独立糖尿病研究人员的成功记录，我们的目标是指导一批新的儿科内分泌学家，他们将成为美国未来儿科糖尿病项目的领导者。每年，我们将为3名儿科内分泌学奖学金项目的应届毕业生提供长达3年的职业发展和支持。Joslin糖尿病中心和波士顿儿童医院非常适合这一机构职业发展奖，因为我们有广泛的教师导师团队，多学科培训计划，致力于在与1型糖尿病相关的研究方面指导博士后和博士后研究员和初级教师，以及我们提供的多样化、有才华的K12计划候选人人才库。应用的理由包括：儿童1型和2型糖尿病的发病率增加，需要发现1型和2型糖尿病的根本原因，在年轻人中实现最佳血糖控制的挑战，短期和长期糖尿病并发症的高风险，需要额外的研究来增加我们对罕见的糖尿病遗传形式的了解，需要在儿童中实施和保持强化胰岛素治疗和新的监测技术，以及需要训练有素和有决心的儿科糖尿病研究人员推进旨在治疗、预防和治愈这些疾病的研究。鉴于我们机构糖尿病研究的历史和哈佛医学院丰富的环境，这一联合申请为致力于儿科糖尿病职业生涯的儿科内分泌学家提供了一个独特的职业发展环境。联合首席调查员兼项目总监Lori Laffel医学硕士和联合首席调查员莫里斯·怀特博士在咨询委员会的支持下，处于协调这一努力的最佳位置。乔斯林的NIH支持的糖尿病研究中心(前DERC)、哈佛的CTSA和哈佛的催化剂计划促进了职业发展。我们始终证明有能力吸引高素质的候选人加入我们的培训计划，并期待着迎接挑战，培养儿科内分泌学家作为儿科糖尿病研究人员的职业生涯。

DESCRIPTION (provided by applicant): This application aims to foster the career development of a diverse and exceptionally well trained group of pediatric endocrinologists entering the field of pediatric diabetes research through a joint institutional career development program at the Joslin Diabetes Center and Children's Hospital Boston. Through mentored training of pediatric endocrine scholars who have completed fellowships in pediatric endocrinology, this joint program will support and nurture career development of junior faculty in biomedical and behavioral diabetes investigation relevant to type 1 diabetes. Based upon the longstanding history of collaboration between the Joslin Diabetes Center and Children's Hospital Boston, our extensive diabetes research programs, and our record of successful career development of pediatric endocrinologists becoming independent diabetes researchers with support from our recently completed K12 career development grant for pediatric diabetologists, we aim to mentor a new group of pediatric endocrinologists who will become future leaders of pediatric diabetes programs in the United States. Each year we will provide career development and support for up to 3 years for 3 recent graduates of pediatric endocrinology fellowship programs. The Joslin Diabetes Center and the Children's Hospital Boston are ideally suited for this institutional career development award due to our extensive group of faculty mentors, multi-disciplinary training programs, commitment to mentoring pre- doctoral and post-doctoral fellows and junior faculty in research relevant to type 1 diabetes, and our available pool of diverse, talented candidates for appointment to the K12 program. The rationale for the application includes: the increased occurrence of both type 1 and type 2 diabetes in childhood, the need to discover the root causes of type 1 and type 2 diabetes, the challenges of achieving optimal glycemic control in youth, the high risk of short- and long-term diabetes complications, the need for additional research to increase our understanding of uncommon genetic forms of diabetes, the demands of implementing and maintaining intensive insulin therapy and new monitoring technologies in children, and the need for trained and committed pediatric diabetes investigators to advance research aimed at treating, preventing and curing these disorders. Given the history of diabetes research at our institutions and the richness of the Harvard Medical School environment, this joint application offers a unique setting for career development of pediatric endocrinologists committed to careers in pediatric diabetes. Co-Principal Investigator and Program Director Lori Laffel MD MPH and Co-Principal Investigator Morris White PhD, supported by an Advisory Committee, are in optimal positions to orchestrate this endeavor. Career development is enhanced by Joslin's NIH-supported Diabetes Research Center (formerly DERC), Harvard's CTSA, and Harvard's Catalyst Program. We have consistently demonstrated the ability to attract highly qualified candidates to our training programs and look forward to meeting the challenge of nurturing the careers of pediatric endocrinologists as pediatric diabetes investigators.