Joint Initiative in Vaccine Economics, Phase 4

项目摘要 意义：随着新疫苗的上市，疫苗经济学研究的需求将增加， 疫苗接种计划的预算限制。这项研究的目的是为疫苗政策提供信息 免疫实践咨询委员会（ACIP），CDC， 以及其他州和地方决策者。 具体目标：拟议的研究旨在解决疫苗政策中的关键问题：（1）潜在的健康和 提高疫苗接种覆盖率的经济效益;（2）疫苗风险-效益权衡的社会价值;以及 (3)公众对青少年和成人疫苗接种环境的偏好。 调查人员和环境：该应用程序要求继续支持一个非常成功的 疫苗经济学联合倡议（JIVE）是一项全球性合作倡议，现已进入第十个年头。JIVE项目 包括在广泛的经济评估和决策科学方面具有丰富经验的调查人员 方法包括成本效益分析、效益成本分析、条件价值评估和联合评估。 分析，以及建模方法的相关专业知识。疫苗经济学联合倡议 在哈佛大学的合作研究人员之间支持合作研究的悠久历史，该大学 密歇根州，和疾病控制和预防中心（CDC）。 创新和研究战略：总体方法是利用经济和决策分析方法， 为疫苗政策决策提供依据。初步研究将衡量 疫苗接种覆盖率对健康结果、成本和成本效益的影响， 美国疫苗接种经济价值的理论模型和使用动态 仿真建模我们建议对预计具有高政策影响的主题进行两项额外研究：风险- 疫苗接种相关不良事件的利益权衡;成人疫苗接种的障碍和促进因素。的 所提出的方法利用经济和建模方法，包括动态仿真模型， 多标准决策分析和联合分析，尚未广泛应用于疫苗政策 问题.研究小组将与疾病预防控制中心的调查人员一起确定与政策相关的主题， 制定适当的研究计划。

PROJECT SUMMARY Significance: As new vaccines become available, the need for vaccine economics research will increase due to budget constraints for vaccination programs. The objective of this research study is to inform vaccine policy recommendations under consideration by the Advisory Committee for Immunization Practices (ACIP), CDC, and other state and local decision makers. Specific Aims: The proposed research studies addresses key issues in vaccine policy: (1) potential health and economic benefits of improved vaccination coverage; (2) societal values for vaccine risk-benefit tradeoffs; and (3) public preferences for adolescent and adult vaccination settings. Investigators and Environment: This application requests continued support for a highly successful collaboration, the Joint Initiative in Vaccine Economics (JIVE), which is now in its tenth year. The JIVE project includes investigators with broad experience in a wide range of economic evaluation and decision science methods including cost-effectiveness analysis, benefit-cost analysis, contingent valuation, and conjoint analysis, as well as related expertise in modeling methods. The Joint Initiative in Vaccine Economics has a long history of supporting collaborative research among co-investigators at Harvard University, the University of Michigan, and the Centers for Disease Control and Prevention (CDC). Innovation and Research Strategy: The overall approach is to use economic and decision analysis methods to provide evidence to inform vaccine policy decisions. The initial study will measure the economic value of changes in vaccination coverage on health outcomes, costs, and cost-effectiveness, by developing a theoretical model of the economic value of vaccination for the US and an empirical model using dynamic simulation modeling. We propose two additional studies on topics anticipated to have high policy impact: risk- benefit tradeoffs for vaccination-related adverse events; barriers and facilitators to adult vaccination. The proposed methods draw on economic and modeling approaches, including dynamic simulation models, multiple-criteria decision analysis, and conjoint analysis, that have not been widely applied to vaccine policy questions. Jointly with investigators from CDC, the research team will identify topics of policy relevance and develop the appropriate research plan.