Cell Analysis and Specimen Banking

细胞分析和标本库核心旨在通过集中常规程序（目标1）和集中组织和标本库程序（目标2）来支持临床和基础科学项目。这些包括样品采集、处理、表征、银行和分发；细胞分类;分析流式细胞术。骨髓瘤研究和治疗研究所（MIRT）每年治疗来自美国和世界各地的近5000名患者。从这个广泛的患者基础中，Core B储存了数千例患者标本，其中许多标本是在患者的疾病和治疗过程中连续收集的。集中的样本采集和存储，加上增强的数据库功能，是程序项目调查人员的巨大资源，也是一种高效的操作。它将允许我们跟踪样本并维护所使用的每个样本的预期数据记录，从而提高所有项目的数据收集效率。不断更新的综合数据库将加强核心的这些活动。由项目负责人和项目负责人组成的核心监督委员会将建立样本分发的优先清单，并将定期更新，以适应不同项目的要求，如细胞数量、样本类型和患者特征。该机制将大大提高不同项目对样品的利用效率。集中的样品处理服务将避免在每个研究者的实验室建立程序的需要，提供统一的程序和有效的材料使用。所提供的流式细胞术和细胞分选服务将为该项目提供最先进的支持，并将由核心人员的专业知识加以增强。

The Cell Analysis and Specimen Banking Core is designed to support the clinical and basic science projects by centralizing common procedures (Aim 1) and centralizing tissue and specimen banking procedures (Aim 2). These include sample acquisition, processing, characterization, banking, and distribution; cell sorting; and analytical flow cytometry. The Myeloma Institute for Research and Therapy (MIRT) annually treats nearly 5,000 patients from across the US and the world. From this extensive patient base, Core B banks thousands of patient specimens, many of which are serially collected throughout the course of a patient's disease and treatment. Centralized sample acquisition and storage, together with enhanced database capabilities, is a tremendous resource for program project investigators, as well as a highly efficient operation. It will allow us to track samples and maintain records of expected data for each sample used, thus increasing the efficiency of data collection for all projects. These activities of the core will be enhanced by a constantly updated integrated database. A priority list for sample distribution will be established by the Core Oversight Committee, composed of the program PI and Project Leaders, and will be updated periodically to accommodate requirements of the different projects, such as cell numbers, sample type, and patient characteristics. This mechanism will greatly increase the efficiency of sample utilization by the different projects. A centralized sample processing service will avoid the need to establish the procedures in each investigator's laboratory, providing for uniform procedures and efficient use of materials. The flow cytometry and cell-sorting services offered will provide state-of-the-art support to the projects in this program application, which will be augmented by the expertise of core personnel.