Training in Cellular & Molecular Mechanisms of Tumor Rejection

参见说明）： 今天在美国，50岁的奥尔兹和5岁的人一样多，30年后， 许多80岁以上的人认为是5岁以下的人（www.census.gov/ipc/www/idbpvr.htmn.作为老年病，癌症 即使不会成为流行病，也将是一个巨大的公共卫生问题。这个特殊的问题提出了一个 基础和应用生物医学研究科学家面临的巨大挑战是提出非凡的想法， 都了解这种疾病，并管理，治疗或预防它。在许多国家， 科学学科，但还有很多东西需要学习，发现和应用。这项工作将由 新一代的生物医学科学家，我们现在正在我们的实验室里训练。的总目标 我们的培训计划是培养一批年轻的免疫学家。博士和MD/PhDs。他们会把它变成 使命是了解如何利用免疫系统对抗癌症。免疫 癌症的解决方案将在于我们能够引发有效的，强有力的免疫反应，具有终身记忆， 与自身分子没有太大区别的抗原。这一令人兴奋的研究领域将继续 为在最新范例方面训练有素的年轻科学家提供挑战和机会， 免疫学在匹兹堡大学医学院，我们成功地培养了 在肿瘤免疫学领域产生重大影响的研究人员。我们建议继续 通过继续我们的培训计划，招募最优秀和最聪明的人进入癌症免疫学， 肿瘤排斥的细胞和分子机制。该培训补助金支持的目标是 为学生和研究员提供课程，研究项目，高素质的导师和财务 资源：1。阐明肿瘤特异性免疫启动的基本机制; 2.定义 抗肿瘤免疫应答中的效应子机制;和3.了解以下要求 建立长期抗肿瘤免疫记忆; 4.阐明肿瘤的具体特征 影响抗肿瘤免疫的微环境; 5.阐明炎症与 癌我们通过精心策划和组织的课程活动来实现这些目标， 结合促进项目教师之间实质性沟通的项目活动， 实习生 相关性（参见说明）：

Seeinstructions): In the United Sates today there are as many 50-year olds as 5-year olds, and in 30 years there will be as many people over 80 as under 5 (www.census.gov/ipc/www/idbpvr.htmn. As the disease of old age, cancer will remain a great public health problem, if not become an epidemic. This extraordinary problem presents a great challenge to basic and applied biomedical research scientists to come up with extraordinary ideas to both understand the disease and manage, cure or prevent it. The progress has been impressive in many scientific disciplines but a lot remains to be learned, discovered and applied. This work will be carried out by the new generation of biomedical scientists that we are now training in our laboratories. The overall goal of our training program is to train a cadre of young immunologists. PhDs and MD/PhDs. who will make it their mission to understand how to harness the immune system in the fight against cancer. Immunological solutions to cancer will lie in our ability to elicit effective, potent immune responses, with life long memory, against antigens that are not much different then self-molecules. This exciting field of research continues to provide challenges and opportunities for young scientists well trained in the newest paradigms in immunology. At the University of Pittsburgh School of Medicine we have successfully trained talented investigators who have made significant impact in the field of tumor immunology. We propose to continue to recruit the best and the brightest into cancer immunology through the continuation of our training program in Cellular and Molecular Mechanisms of Tumor Rejection.The goals supported by this training grant are to provide students and fellows with courses, research projects, highly qualified mentors and financial resources to: 1. Elucidate the basic mechanisms of initiation of tumor-specific immunity; 2. Define the effector mechanisms in the anti-tumor immune response; and 3. Understand the requirements for establishment of long-term anti-tumor immune memory; 4. Elucidate specific features of the tumor microenvironment that affect anti-tumor immunity; 5. Elucidate the relationship between inflammation and cancer. We have been accomplishing these goals through well-planned and organized course activities, combined with program activities that promote substantive communication among the program faculty and trainees. RELEVANCE (See instructions):