Transcriptional Regulation During Cell Growth; Differentiation and Development

描述（由申请人提供）：本申请寻求FASEB夏季会议“细胞生长、分化和发育过程中的转录调控”的部分资金，该会议将于2012年7月15日至20日在科罗拉多州斯诺马斯举行。这次会议是1990年首次举行的非常成功的两年期会议的延续。本次会议的目标是汇集科学家感兴趣的转录和染色质调控的分子基础，在生物体发育的背景下。目前，有优秀的会议转录和独立的发育生物学，但有相对较少的重叠，在这两个领域的大多数科学家参加单独的会议。会议形式将包括九个上午和晚上的简短会谈，然后是讨论，下午是非正式互动和四个海报会议。九场演讲将涵盖经典主题以及发展转录控制的新兴领域：多能性，转录因子选择性和细胞命运规范，转录控制的非编码RNA，跨代信号传导，核组织，梯度解释，小的非编码RNA和转录沉默，随机性和鲁棒性。通过最大化正式讨论和非正式互动，FASEB细胞生长，分化和发育过程中的转录调控会议将有助于定义该领域的现状和未来。去年春天邀请了潜在的演讲者，几乎所有人都积极热情地回应了。会议将以既有研究人员和初级教师为特色，提供令人兴奋的新研究项目。为了呼吁 为了更广泛的社区和保持活跃的环境，我们招募了许多在2008年或2010年没有出席的演讲者。根据这一标准，我们66%的发言者是新来的。会议有三个额外的特点，使其独特的。1)它有意跨越各种各样的实验系统，并专注于特殊活动或承诺的领域。这导致了富有成效的分析，并提出了关于潜在机制的新问题。研究人员有机会讨论转录和信号网络如何整合以指导正常与疾病状态下的细胞命运的全貌。2)我们组织了一个由38名优秀研究人员组成的项目，他们研究转录、发育和癌症生物学。他们不仅代表了该领域中最具生产力和创造力的成员，而且也代表了有能力开展富有成果的讨论的个人。我们将从提交的摘要中再邀请16位演讲者，以突出即将到来的初级研究人员。我们预计将有100-150名与会者参加一个活跃的会议。3)2012年的会议将在科罗拉多的斯诺马斯举行，这是一个地理位置孤立的地点，与会者可以在五天的深入讨论中保持密切联系。 公共卫生相关性：资金要求部分支持为期5天的FASEB夏季研究会议“细胞生长，分化和发育过程中的转录调控”，这将在斯诺马斯，科罗拉多7月15日至20日，2012年举行。许多人类疾病和障碍，包括癌症和先天性出生缺陷，都与发育缺陷有关，这些发育缺陷在很大程度上受到基因转录模式改变的控制。尽管在了解染色质重塑，基因转录和特定发育过程之间的联系方面取得了很大进展，但没有其他会议致力于将这两个领域结合在一起。本次FASEB会议的目的是汇集转录控制和发育生物学领域的优秀研究人员进行信息交流，从而促进合作和更快地解决基本问题。会议有三个特点，使其独特。1)它有意跨越各种各样的实验系统，并专注于特殊活动或承诺的领域。这导致了富有成效的分析，并提出了关于潜在机制的新问题。研究人员有机会讨论转录和信号网络如何整合以指导正常与疾病状态下的细胞命运的全貌。2)我们组织了一个由38名优秀的研究人员组成的项目，他们研究转录、发育和癌症生物学。我们的演讲者包括该领域的领导者以及刚刚建立自己的研究计划的新研究人员。他们将突出多样化和尖端的方法，以促进我们对细胞生长，分化和发育过程中基因网络调控的理解。我们预计将有100至150名与会者参加一个活跃的会议。3)2012年的会议将在科罗拉多的斯诺马斯举行，这是一个地理位置孤立的地点，与会者可以在五天的深入讨论中保持密切联系。

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Conference "Transcriptional Regulation during Cell Growth, Differentiation, and Development" to be held July 15 - 20, 2012 in Snowmass, Colorado. This conference represents a continuation of the highly successful biennial meeting that was first held in 1990. The goal of this meeting is to bring together scientists interested in the molecular underpinnings of transcription and chromatin regulation, in the context of organismal development. Currently, there are outstanding conferences on transcription and independently also on developmental biology, but there is relatively little overlap between the two, and most scientists in the two fieds attend separate meetings. The conference format will consist of nine morning and evening sessions of short talks followed by discussion and, in the afternoon, informal interactions and four poster sessions. The nine presentation sessions will cover classic topics as well as emerging areas in transcriptional control of development: pluripotency, transcription factor selectivity and cell fate specification, non-coding RNAs for transcriptional control, trans-generational signaling, nuclear organization, interpretation of gradients, small noncoding RNAs and transcriptional silencing, stochasticity and robustness. By maximizing both formal discussion and informal interactions, the FASEB conference on Transcriptional Regulation during Cell Growth, Differentiation, and Development will help to define both the present state and the future of the field. Prospective speakers were invited last spring, and almost all responded positively and with enthusiasm. The meeting will feature both established investigators and junior faculty with exciting new research programs. In an effort to appeal to the broader community and to maintain a lively environment, we have recruited many speakers who did not present in 2008 or 2010. By this criterion, 66% of our speakers are new to the meeting. The conference has three additional features that make it unique. 1) It intentionally spans a wide variety of experimental systems and focuses on areas of exceptional activity or promise. This leads to fruitful analyses and raises new questions about underlying mechanisms. Investigators have the opportunity to discuss the complete picture of how transcription and signaling networks are integrated to guide cell fate in normal vs. diseased states. 2) We have organized a program of 38 outstanding investigators who study transcription, development and cancer biology. They represent not only some of the most productive and creative members in the field, but also individuals with the capacity to generate fruitful discussions. We will invite 16 more speakers from the submitted abstracts, to highlight upcoming junior investigators. We anticipate a lively conference of 100-150 attendees. 3) The 2012 meeting will be held in Snowmass, Colorado, a geographically isolated site that keeps participants in close proximity for five days of in-depth discussion. PUBLIC HEALTH RELEVANCE: Funding is requested for partial support of a 5 day FASEB Summer Research Conference on "Transcriptional Regulation during Cell Growth, Differentiation, and Development", which will be held in Snowmass, Colorado July 15-20, 2012. Many human diseases and disorders, including cancer and congenital birth defects, are related to defective developmental events that are controlled in large part by altered patterns of gene transcription. Despite great progress in understanding how chromatin remodeling, gene transcription, and specific developmental processes are linked, there is no other meeting dedicated to bringing these two fields together. The purpose of this FASEB conference is to bring together outstanding researchers in the areas of transcriptional control and developmental biology for information exchange, thereby fostering collaboration and more rapid progress towards fundamental problems. The conference has three features that make it unique. 1) It intentionally spans a wide variety of experimental systems and focuses on areas of exceptional activity or promise. This leads to fruitful analyses and raises new questions about underlying mechanisms. Investigators have the opportunity to discuss the complete picture of how transcription and signaling networks are integrated to guide cell fate in normal vs. diseased states. 2) We have organized a program of 38 terrific investigators who study transcription, development and cancer biology. Our speakers include both leaders in the field as well as new investigators just establishing their own research programs. They will highlight diverse and cutting edge approaches to advancing our understanding of the regulation of gene networks during cell growth, differentiation, and development. We anticipate a lively conference of 100 to 150 attendees. 3) The 2012 meeting will be held in Snowmass, Colorado, a geographically isolated site that keeps participants in close proximity for five days of in-depth discussion.