In Vivo Imaging of Neoplasia

概述：在最初的资助期间，该计划通过其研究人员的联合创造性努力，在分子成像方面取得了重大进展。分子成像的这些进展导致了新型分子成像报告分子的发展，这些报告分子已被用于提高我们对癌症病因学、生物学、病理生理学和治疗的理解。在这个更新的ICMIC应用中，我们将继续开发用于肿瘤前（发育不良）组织和体内致癌信号分子成像的前沿方法。项目1将开发一种集成的光学分子成像策略，使用荧光肽作为探针来靶向体内癌前（发育不良）组织的存在。该项目将开发新型光学成像探针和仪器，既可用于临床前模型，也可用于临床，作为中空器官早期癌症检测的实用筛查工具。项目2将开发和验证分子成像报告基因（即EGFR、Met和Akt）。细胞和动物的非侵入性成像将用于评估这些新的报告结构，以检测关键的致癌信号通路。项目3将开发用于胶质瘤信号通路成像和胶质瘤干细胞亚群成像的分子成像工具。这些工具和概念将极大地帮助我们的临床前药物开发过程，并为脑肿瘤更有效的联合治疗策略提供见解。该提案包括一个职业发展计划，提供培训和互动的机会，年轻的，热情的分子成像研究者。该试点计划将通过提供资金、想法和资源来促进正在进行的研究，从而招募优秀的科学家到分子成像领域。核心A，行政核心将为所有项目提供行政和统计支持，并将促进所有项目的外部和内部科学审查。成像核心（Core B）将为本次ICMIC的所有动物成像需求提供成像专业知识和设备。生物统计核心（核心C）将为所有项目、试点项目和职业发展奖获得者提供所有生物统计分析。UM-ICMIC项目的中心目标之一是弥合巨大的鸿沟

OVERVIEW: During the initial funding period, the program has made significant advances in molecular imaging through the combined creative efforts of its investigators. These advances in molecular imaging have led to the development of novel molecular imaging reporter molecules which have been used to improve our understanding of cancer etiology, biology, pathophysiology and therapy. In this renewal ICMIC application, we will continue to develop cutting edge approaches for imaging the presence of pre-malignant (dysplastic) tissue and oncogenic signaling molecules in vivo. Project 1 will develop an integrated optical molecular imaging strategy that uses fluorescence peptides as probes to target the presence of premalignant (dysplastic) tissue in vivo. This Project will develop novel optical imaging probes and instruments that can be used in pre-clinical models as well as translated to the clinic as practical screening tools for the early detection of cancer in hollow organs. Project 2 will develop and validate molecular imaging reporters (i.e. EGFR, Met and Akt). Non-invasive imaging in cells and animals will be used to evaluate these novel reporter constructs for detection of key oncogenic signaling pathways. Project 3 will develop molecular imaging tools for imaging of signaling pathways in gliomas and for imaging of the glioma stem cell subpopulation. These tools and concepts should significantly aid in our preclinical drug development process and provide insights into more efficacious combination therapy strategies for brain tumors. The proposal includes a Career Development Program which provides the opportunity to train and interact with young, enthusiastic molecular imaging investigators. The Pilot Program will enable recruitment of outstanding scientists to the molecular imaging field by providing funding, ideas and resources to facilitate ongoing research. Core A, the administrative core will provide administrative and statistical support to all projects and will also facilitate External and Internal scientific review of all projects. The imaging Core (Core B) will provide imaging expertise and equipment for all of the animal imaging needs of this ICMIC. The Biostatistics Core (Core C) will provide for all of the biostatistical analysis of all of the Projects, Pilot Projects and Career Development Awardees. One of the central goals of the UM-ICMIC program is to bridge the great divide between quality patient care and laboratory studies in cancer research. This continues to be the driving force in the current proposal.