FASEB SRC on Mitosis: Spindle Assembly and Function

描述(申请人提供)：细胞分裂(有丝分裂)是细胞周期的顶峰，即使是控制有丝分裂的分子机制中看似微小的缺陷，也会深刻地影响子细胞的命运，并最终影响整个有机体的命运。一个 一系列的病理，如基因组不稳定、癌症或出生缺陷，都是由有丝分裂装置(纺锤体)的不正确形成引起的。因此，对有丝分裂的研究是美国国立卫生研究院改善公共卫生任务的重点。大量的科学家将他们的研究集中在有丝分裂装置的各个方面。事实上，有丝分裂领域融合了分子细胞生物学、生物化学、生物物理学、计算生物学和功能基因组学。为了促进信息和思想的交流，以及鼓励新的跨学科合作，我们寻求资金来支付由FASEB主办的第三次“有丝分裂：纺锤体的组装和功能”会议的部分费用。这次国际会议由印第安纳大学(美国印第安纳州布鲁明顿)的Claire Walczak教授和巴塞尔大学(瑞士巴塞尔)Biozentum的Erich Nigg教授组织，将汇集来自有丝分裂领域不同子学科的约175名研究人员。会议将由沃兹沃斯中心(纽约州奥尔巴尼)的康利·里德博士发表主旨演讲，沃兹沃斯中心是该领域的长期领导者。讲台上将邀请国际知名专家，如 以及年轻的科学家，他们的工作将从提交的摘要中挑选出来。会议将举行9个平台部分，涵盖有丝分裂的所有主要方面：1.有丝分裂纺锤体组装；2.有丝分裂的定量方法；3.中心体结构和功能；4.着丝粒组装和功能；5.染色体结构和功能；6.有丝分裂生涯研讨会；7.胞质分裂和有丝分裂退出；8.染色体分离和非整倍体；9.发育中的有丝分裂。为了补充平台会议，将分配时间用于三次海报会议，每次2小时。这次会议每三年举行一次，是FASEB赞助的系列会议的一部分，是唯一完全专注于有丝分裂的定期国际会议。 公共卫生相关性：有丝分裂纺锤体将遗传物质忠实地分离到子细胞，这对有机体的生存至关重要。由于这一过程中的缺陷可能导致基因组不稳定、出生缺陷和癌症，因此对这一基本过程的研究与人类健康和美国国立卫生研究院的使命有关。因此，将研究有丝分裂各个方面的研究人员聚集在一起的计划将加强对这一重要生物学过程的理解。

DESCRIPTION (provided by applicant): Cell division (mitosis) is the culmination of the cell cycle, and even seemingly minute deficiencies in the molecular mechanisms that control mitosis profoundly affect the fate of the daughter cells and ultimately, the fate of the entire organism. A range of pathologies, such as genomic instability, cancer, or birth defects arise from improper formation of the mitotic apparatus (spindle). Thus, research on mitosis is the focus of the NIH mission to improve public health. A vast number of scientists focus their investigations on various aspects of mitotic apparatus. In fact, the field of mitosis amalgamates molecular cell biology, biochemistry, biophysics, computational biology, and functional genomics. To foster exchange of the information and ideas, as well as to encourage new interdisciplinary collaborations we seek funds to partially defray the cost of the 3rd FASEB-sponsored meeting on "Mitosis: Spindle Assembly and Function". This international meeting, organized by professors Claire Walczak of Indiana University (Bloomington, Indiana, USA) and Erich Nigg of Biozentrum, University of Basel (Basel, Switzerland), will bring together approximately 175 researchers from the various sub-disciplines within the field of mitosis. The meeting will feature a keynote address by Dr. Conly Rieder of the Wadsworth Center (Albany, NY), a long-standing leader in the field. Podium presentations will feature invited internationally-renowned experts, as well as younger scientists whose work will be selected from the submitted abstracts. Nine platform sections covering all major aspects of mitosis will be held: 1. Mitotic spindle assembly; 2. Quantitative approaches to mitosis; 3. Centrosome structure and function; 4. Kinetochore assembly and function; 5. Chromosome structure and function; 6. Mitosis career symposium; 7. Cytokinesis and mitotic exit; 8. Chromosome segregation and aneuploidy; 9. Mitosis in Development. To complement the platform sessions, time will be allocated for three poster sessions, each 2 hours long. This meeting, held every three years as part of the FASEB-sponsored series, is the only regular international conference that focuses entirely on mitosis. PUBLIC HEALTH RELEVANCE: The faithful segregation of genetic material by the mitotic spindle to daughter cells is essential for the survival of an organism. Because defects in the process can contribute to genomic instability, birth defects, and cancer, the study of this fundamental process is relevant to human health and the mission of the NIH. The plan to bring together researchers who study all aspects of mitosis will therefore enhance the understanding of this important biological process.