Western Regional Center of Excellence for Biodefense and Emerging Infectious Dise

西部地区生物防御和新发传染病研究卓越中心(WRCE)的使命是创建协同、多方面的研究、强大的基础设施，以及通过应用最好的基础和翻译科学来开发针对自然和人为新发传染病威胁的疫苗、疗法和诊断方法的活动。来自22个机构的科学家建议开展15个重大研究项目，并提供6项支持性核心活动。WRCE是德克萨斯州、新墨西哥州、俄克拉何马州、阿肯色州和路易斯安那州合作研究传染病的联合力量。对国家RCE计划的评估显示，WRCE在生物防御方面的新调查人员数量、项目数量、研究的生物体数量、专利申请数量以及来自RCE项目的其他资金支持的新项目数量方面表现最好。成功的基础科学家在A-C类代理方面拥有丰富的专业知识，他们真正接受了面向翻译产品的研究这一陌生目标。这15个主要项目涉及四个主题：RNA病毒治疗试剂的开发，A-C类药物和新兴药物的多重诊断平台，虫媒病毒和新出现的病毒疾病的疫苗开发，以及细胞内细菌引起的疾病的疫苗开发。这15个项目目前正在追求新的具体目标；这是世界资源、环境和经济委员会在上一个赠款周期中支持发展型赠款以启动下一阶段项目的战略的结果，以及在周期结束前一年对主要项目的提前竞争。在这一规划过程中，可以选择最好、最相关的科学，并在主题范围内发展协同作用。行政核心对进度报告、现场访问、区域会议、讲习班和正式的外部产品开发协商的分析提供认真指导，支持研究活动，并每月举行主题会议，以确保项目继续取得成功。高生产率的科学家利用地区来源，如三个国家灵长类研究中心，19个拥有BSL-3实验室的机构，两个拥有BSL-4实验室的机构，两个疫苗开发中心，两个能源部国家实验室，13所参与的医科大学，三所参与的兽医学校，以及四个拥有空气生物学专业知识的机构，将他们杰出的科学知识转化为一个比其部分总和更多的计划。

The mission of the Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (WRCE) is the creation of synergistic,.multifaceted research, strong infrastructure, and activities to develop vaccines, therapeutics, and diagnostics against natural and manmade emerging infectious disease threats by applying the best basic and translational science. Scientists from 22 institutions propose to conduct 15 major research projects and provide six supportive core activities. The WRCE is a unifying force in Texas, New Mexico, Oklahoma, Arkansas, and Louisiana for collaborative research on infectious diseases. The evaluation of the national RCE program revealed that the WRCE was the top performer in the number of new investigators in biodefense, number of projects, number of organisms studied, number of patents filed, and number of new projects supported by other funds that stemmed from RCE projects. Successful basic scientists with substantial expertise in Category A-C agents have truly embraced the unfamiliar goal of translational product-oriented research. The 15 major projects address four themes: development of therapeutic agents for RNA viruses, platforms for multiplexed diagnostics for Category A-C agents and emerging agents, vaccine development for arboviral and emerging viral diseases, and vaccine development for diseases caused by intracellular bacteria. The 15 projects are currently pursuing new specific aims; this is a result of the WRCE's strategy in the previous grant cycle to support developmental type grants to initiate next-stage projects, and an early competition for major projects one year before the completion of the cycle. This planning process allowed selection of the best, most relevant science and development of synergistic interactions within the themes. Attentive guidance by the administrative core's analysis of progress reports, site visits, regional meetings, workshops, and formal external product development consultations support research activities, along with monthly theme meetings to ensure the continued success of projects. Highly productive scientists utilize such regional sources as three national primate research centers, 19 institutions with BSL-3 laboratories, two institutions with BSL-4 laboratories, two vaccine development centers, two DOE national laboratories, 13 participating medical universities, three participating veterinary schools, and four institutions with aerobiology expertise to translate their outstanding scientific knowledge into program that delivers more than the sum of its parts.