Graduate Training in Biochemistry and Molecular Biology

描述(由申请人提供)：生物化学，分子和细胞生物学，培养计划目前有43名博士生正在攻读该学位。2008年秋季一年级录取了10名新生。这些研究兴趣从生物化学：金属结合蛋白和核酸结合蛋白的X射线结晶学分析，热休克蛋白功能，核苷酸合成的酶学，脂肪酸/硫辛酸生物合成的调控，以及脂联素信号，到分子生物学：基因组结构分析，DNA修复和染色体不稳定性，RNA处理，周转和运输，细胞生物学：癌细胞发生和转移的调控，细胞器的生物发生和放置，细胞骨架结构和功能，到发育：控制模式形成的信号通路，发育计划的进化，心脏发育。二年级及以上的学生将根据成绩被挑选出来，最多两年由这笔培训补助金资助。所有BMCB学生将参加每周一次的期刊俱乐部和研讨会项目；每名学生每年至少做一次演讲。一年一度的静修活动，每个学生要么展示一张海报，要么发表一次演讲，这是BMCB长期存在的传统。一年级和二年级的学生完成一系列课程，其中包括核酸、蛋白质和酶。生物化学专业的学生选修生物结构课程，MCB专业的学生选修细胞系统专业。为对生物信息学感兴趣的学生提供的新途径将包括一门计算机辅助基因组分析的课程。由于预计我们的许多毕业生将成为教授、教师和/或实验室负责人，所有学生都将在亚利桑那大学的本科生物化学和分子与细胞生物学课程中接受至少一个学期的助教培训。学生将参加一年一度的强制性会议，审查来年的计划要求，并将独立监测计划里程碑的进展情况。所有学生都将有一个教职员工指导委员会，每年至少召开一次会议。

DESCRIPTION (provided by applicant): The BMCB, Biochemistry, Molecular and Cellular Biology, Training Program presently has 43 Ph.D. students working toward the degree. Ten new students have been admitted for the 2008 Fall first-year class. These research interests range from biochemistry: x-ray crystallographic analysis of metal binding and nucleic acid binding proteins, heat shock protein function, enzymology of nucleotide synthesis, regulation of fatty acid/lipoic acid biosynthesis, and adiponectin signalling, to molecular biology: genome structure analysis, DMA repair and chromosome instability, RNA processing, turnover and transport, to cellular biology: regulation of cancer cell genesis and metastasis, organelle biogenesis and placement, cytoskeleton structure and function, to development: signaling pathways governing pattern formation, evolution of developmental programs, heart development. Students in the second year and beyond will be chosen based on merit for a maximum of two years of support by this training grant. All BMCB students will participate in weekly journal club and seminar programs; each year each student will give at least one presentation. A yearly retreat where each student either presents a poster or a talk is a long-standing BMCB tradition. First and second year students complete a set of courses that includes Nucleic Acids and Proteins and Enzymes. Students in the Biochemistry track take Biological Structure and those in the MCB track take Cellular Systems. A new track for students interested in Bioinformatics will include a course in computer-aided analysis of genomes. In anticipation that many of our graduates will become professors, teachers and/or laboratory heads, all students will be trained as teaching assistants in the undergraduate Biochemistry and Molecular and Cellular Biology classes at the University of Arizona for at least one semester. Students will attend yearly mandatory meetings to review program requirements for the upcoming year and will be monitored independently for progress through the milestones of the program. All students will have a faculty mentoring committee that will meet at least once a year.