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Graduate Training in Biochemistry and Molecular Biology

生物化学和分子生物学研究生培训

基本信息

批准号：
10631056
负责人：
Andrew Paul Capaldi
金额：
$ 31.83万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10631056
关键词：
Biochemistry Molecular Biology Training

项目摘要

PROJECT SUMMARY The Biochemistry, Molecular and Cellular Biology (BMCB) graduate program at the University of Arizona is an interdepartmental and interdisciplinary graduate program that seeks to equip students with a broad understanding of modern approaches in Biochemistry, Molecular and Cellular Biology, and Systems/ Quantitative Biology, and the way these approaches can be combined to tackle important unsolved problems in Biology and Medicine. To achieve this goal, we focus on ensuring our students develop eight interrelated skills: (1) A broad knowledge of Biochemistry, Molecular Biology and System/Quantitative Biology; (2) A broad interdisciplinary knowledge of experimental/computational approaches; (3) An ability to communicate (and thus think) clearly; (4) An ability to read, evaluate and integrate the scientific literature (5) A deep knowledge in the field of thesis research; (6) An ability to plan and execute experiments; (7) An ability to generate new insights and ideas; (8) An ability to recognize important research problems and questions. Students start developing their foundational skills (1-5) in first year classes; using group work to study key literature, build up their understanding of experimental methods and approaches, and develop good communication skills. At the same time, students do three eight-week rotations to learn the intricacies of experimentation and identify a suitable faculty mentor. Then, as students start their second year, they enroll in a Scientific Communication course, where they are guided though the process of developing their thesis project, writing it up and submitting it as a fellowship, and presenting it in oral form. Starting in Fall 2019, our students will also take a Quantitative Methods course at the start of their second year, where they will learn to program in R, carry out a range of statistical tests, and then use those skills to analyze images, movies, and large Omics datasets (helping with the rigor and reproducibility of their future research). Students then move on to their Oral and Written exams and begin focusing on their thesis project. At the same time, however, they continue to participate in a number of activities designed to help them refine their skills, remain connected to the BMCB community, and identify and secure a career that works for them. The most important of these are: (1) a new Journal Club and associated Idea Development Workshop that provides students multiple opportunities to develop and refine new ideas and questions each semester; and (2) “Student Only” retreats, career development workshops, and a BMCB internship program, that expose students to a wide variety of professions and help them make the contacts they need to move forward in their career. To help support these activities, we are requesting funds to cover the costs of eight BMCB students per year, approximately 1/3 of our TGE students. Students will be appointed to the training grant for one, or subject to renewal, two years; preferably in their second and third year. Our expectation is that ~90% of students that enter the BMCB program will graduate and go on to have a career in Biological or Biomedical research--regardless of their gender or race--a goal we have met for the last 10 years.

项目摘要亚利桑那大学的生物化学，分子和细胞生物学（BMCB）研究生课程是一个跨部门和跨学科的研究生课程旨在为学生提供广泛的知识了解生物化学，分子和细胞生物学以及系统的现代方法。定量生物学，以及这些方法可以结合起来解决重要的未解决的问题，生物学和医学。为了实现这一目标，我们专注于确保我们的学生发展八个相互关联的技能： (1)生物化学，分子生物学和系统/定量生物学的广泛知识;（2）广泛的实验/计算方法的跨学科知识;（3）沟通能力（因此（4）阅读、评估和整合科学文献的能力;（5）对论文研究领域;（6）计划和执行实验的能力;（7）产生新见解的能力（8）识别重要研究问题和问题的能力。学生开始发展他们的基础技能（1-5）在第一年的类;使用小组工作，研究关键文献，建立他们的理解实验方法和途径，并培养良好的沟通技巧。在同一时间，学生做三个为期八周的轮换，学习实验的复杂性，并确定一个合适的教师导师然后，当学生开始他们的第二年，他们参加了科学传播课程，在那里，他们被引导通过开发他们的论文项目的过程，写出来，并提交它作为一个并以口头形式提出。从2019年秋季开始，我们的学生还将参加定量方法课程在他们的第二年开始，在那里他们将学习在R编程，进行一系列的统计，测试，然后使用这些技能来分析图像，电影和大型组学数据集（有助于严格和未来研究的可重复性）。然后学生们进入口试和笔试阶段，开始专注于他们的论文项目但与此同时，他们继续参加一些活动，旨在帮助他们提高技能，保持与BMCB社区的联系，并确定和确保为他们工作的职业。其中最重要的是：（1）一个新的杂志俱乐部和相关的想法发展研讨会，为学生提供多种机会，发展和完善新的想法，问题每学期;和（2）“学生只”务虚会，职业发展研讨会，和BMCB 实习计划，让学生接触各种各样的职业，并帮助他们建立联系，需要在职业生涯中向前迈进。为了帮助支持这些活动，我们正在申请资金，每年8名BMCB学生的费用，约占TGE学生的1/3。学生将被任命为培训补助金为期一年，或可延长两年;最好是在第二年和第三年。我们预计进入BMCB课程的学生中有90%将毕业，并继续在生物学或生物医学研究-不分性别或种族-这是我们在过去10年里实现的目标。

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Designing combination therapies with modeling chaperoned machine learning.

通过建模陪伴机器学习来设计联合疗法。

DOI：
10.1371/journal.pcbi.1007158
发表时间：
2019
期刊：
PLoS computational biology
影响因子：
4.3
作者：
Zhang,Yin;Huynh,JulieM;Liu,Guan-Sheng;Ballweg,Richard;Aryeh,KayenatS;Paek,AndrewL;Zhang,Tongli
通讯作者：
Zhang,Tongli

Targeted for destruction: degradation of singlet oxygen-damaged chloroplasts.