Intervention to Prevent Delayed Diagnosis of Oral Cancer

描述(由申请人提供)：候选人：Alvin G.Wee，BDS，硕士，公共卫生硕士，对临床研究的学术生涯表现出坚定的承诺。这个K23应用程序的目标是在他从事职业发展活动时提供临床研究方面的指导，并辅之以研究计划。这将完成他向独立研究人员的过渡，专注于口腔癌的预防和早期发现。拟议的职业发展活动包括与导师和顾问的预定接触，以及参加相关的研讨会/科学会议、学术课程和暑期计划。环境：俄亥俄州立大学(OSU)健康科学校区提供了一个丰富的环境，拥有广泛的研究活动、成熟的导师和必要的物质资源，以支持这项申请的活动。与这一申请相关的校园部分包括牙科学院、综合癌症中心(CCC)、公共卫生学院以及耳鼻喉科、心理学和内科。所有的导师和顾问都在现场，在各自的领域有充足的资金，并且有指导临床研究人员的经验。初级导师将由俄亥俄州立大学CCC人口科学部副主任、公共卫生学院马里恩·N·罗利癌症研究教授E·D·帕克特提供。其他将提供指导的共同导师和顾问具有与研究计划相关的专业知识。研究：这项建议的总体假设是，与牙医相比，口腔癌高危人群更有可能寻求其他医疗保健专业人员的医疗问题。该研究计划的目标是为初级保健医生开发和测试基于网络的教育干预的可行性，以促进口腔癌的早期发现(目标3)。获得与患者相关的决定因素(目标1)和与口腔癌晚期诊断相关的医疗保健相关决定因素(目标2)的信息都将有助于基于网络的教育干预的发展。相关性：这项申请与2010年《健康人》的两个目标有关：(1)将口腔和咽喉癌最早被发现的比例从基线的35%提高到50%的目标，以及(2)将报告在过去12个月内进行过口腔和咽喉癌检查的成年人的比例从13%的基线增加到20%的目标。

DESCRIPTION (provided by applicant): Candidate: Alvin G. Wee, BDS, MS, MPH has shown strong commitment to an academic career in clinical research. The goal of this K23 application is to provide mentored guidance in clinical research as he engages in career development activities complemented by a research program. This will finalize his transition toward becoming an independent researcher focusing on the prevention and early detection of oral cancer. Proposed career development activities include scheduled contacts with mentors and consultants and attending relevant seminars/scientific meetings, academic courses and summer programs. Environment: Ohio State University (OSU) Health Science Campus provides a rich environment with extensive research activities, established mentors and physical resources necessary to support the activities of this application. Relevant components of the Campus to this application includes the College of Dentistry, Comprehensive Cancer Center (CCC), School of Public Health, and Departments of Otolaryngology, Psychology and Internal Medicine. All mentors and consultants are onsite, are well funded in their fields, and have experience in mentoring clinical researchers. Primary mentorship will be provided by E. D. Paskett, the Marion N. Rowley Professor of Cancer Research at the School of Public Health and Associate Director of Population Sciences, OSU CCC. Other co-mentors and consultants that will provide guidance have relevant expertise to the research program. RESEARCH: The general hypothesis of this proposal is that groups at risk for developing oral cancer are more likely to see other healthcare professionals for their medical problems than dentists. The objective of the research program is to develop and test the feasibility of a web-based educational intervention for primary care physicians to promote early detection of oral cancer (Aim #3). Information obtained on patient-related determinants (Aim #1) and healthcare-related determinants relevant to late stage diagnosis of oral cancer (Aim #2) will both contribute to the development of the web-based educational intervention. RELEVANCE: This application is relevant to two objectives of the Healthy People 2010: (1) to increase the portion of oral and pharyngeal cancer that is detected at the earliest stage, from baseline of 35% to target of 50%, and (2) to increase the portion of adults who report having had an examination to detect oral and pharyngeal cancer in the past 12 months from the 13% baseline to the target of 20%.