A Multi-Center Epidemiologic Study of Breast Cancer in African-American Women

乳腺癌是女性中最常见的癌症，是第二大癌症原因 死亡目前美国的乳腺癌死亡率，包括田纳西州和南卡罗来纳州， 在非裔美国人中比在高加索人中高得多。对病因学知之甚少 我们也不知道什么因素可以解释为什么非裔美国妇女倾向于被诊断为乳腺癌。 比白人女性更容易得侵袭性疾病最近的全基因组关联研究（GWAS） 为研究乳腺癌病因提供了机会。大约有20个易感基因位点已被 在中国和欧洲血统的女性中进行的GWAS中确定。最近的报告发现， 高加索和中国女性的乳腺癌风险持续增加， 其中一些位点。在这项拟议项目的三年期间，我们预计将增加15至20个 乳腺癌易感基因位点将通过GWAS确定，包括我们在亚洲人中进行的研究 妇女这些基因座与非裔美国妇女的相关性仍然调查不足，我们的数据显示， 最近的试点调查表明，大多数最初报告的遗传风险变异， 高加索人和中国人不能在非裔美国人中直接复制。本建议的目的 该项目将调查大约21个GWAS鉴定的基因座，以发现与以下疾病相关的遗传风险变异： 非裔美国女性此外，我们将建立乳腺癌风险评估模型，其中纳入 临床和遗传因素，以更好地确定高风险的非洲裔美国妇女，因为只有现有的乳房 非裔美国人的癌症风险评估模型不包括遗传标记。整个项目将 由癌症外展中心提供支持

Breast cancer, the most frequently diagnosed cancer among women, is the second leading cause of cancer death. Current breast cancer mortality rates in the United States, including Tennessee and South Carolina are considerably higher among African Americans than among Caucasians. Little is understood about the etiology of breast cancer nor do we know what factors might explain why African American women tend to be diagnosed with more aggressive disease than Caucasian women. Recent genome-wide association studies (GWAS) have opened opportunities to investigate breast cancer etiology. Approximately 20 susceptibility loci have been identified from the GWAS conducted among women of Chinese and European ancestry. Recent reports found breast cancer risk consistently increased among Caucasian and Chinese women with an increasing number of some of these loci. During the three years of this proposed project we anticipate an additional 15 to 20 susceptibility loci for breast cancer will be identified through GWAS, including our study conducted among Asian women. The relevance of these loci to African American women remains under-investigated, and data from our recent pilot investigation have showed that the majority of the initially-reported genetic risk variants identified in Caucasian and Chinese cannot be directly replicated among African Americans. The purpose of this proposed project is to investigate approximately 21 GWAS-identified loci to discover genetic risk variants relevant for African American women. In addition, we will establish a breast cancer risk assessment model that incorporates clinical and genetic factors to better identify high-risk African American women since the only existing breast cancer risk assessment model for African Americans does not include genetic markers. This full project will be supported by the Cancer Outreach Core.