Administrative Core

行政核心将主要负责项目管理和协调。虽然我们计划的各个组成部分可以在许多方面独立运作，但未来五年的成功在很大程度上取决于四个主要研究机构的研究人员之间的有效互动。因此，将需要不断保持畅通的沟通渠道，并确保有效率和有成效地开展日常业务。因此，我们计划每个组成部分的主要研究者也将投入时间和精力来计划 在行政核心内进行管理和中央协调。这将鼓励我们的个别项目继续作为一个高度一体化的整体的一部分发挥作用。此外，由于我们的老龄化研究计划已经扩展到包括其他NIH资助的项目，如本申请的介绍中所述，本核心的目的是保持与这些其他工作的合作关系。这些总体目标将通过以下方式实现：（a）管理和协调计划活动;（B）监督行政要求（例如，协调IRB审查和获得知情同意的程序）;（c）向项目研究者提供统计咨询;（d）跟踪不良事件并向监督小组编写必要的报告（例如，合作机构的审查委员会，国家卫生研究院），以及（e）促进生产力和传播研究结果。还将成立一个咨询委员会，审查活动和进展情况，并确保该方案继续：（a）成功实现其目标，（B）在这一迅速发展的领域保持其领导作用。委员会每年举行一次会议， 如有需要，委员会成员可随时提供额外意见。

The Administration Core will have the primary responsibility for Program management and coordination. While the individual components of our Program can function independently in many respects, success during the next five years depends to a substantial degree on effective interactions among investigators at four major research institutions. Therefore, there will be constant needs to maintain open lines of communication, and to ensure that daily operations are carried out both efficiently and effectively. Thus, the Principal Investigator(s) of each component of our Program also will devote time and effort to program management and central coordination within the Administration Core. This will encourage our individual projects to continue to function as parts of a highly integrated whole. In addition, because our Aging Research Program has expanded to include other NIH funded projects as outlined in the introduction of this application, an aim of this Core will be to maintain collaborative relationships with these other efforts. These overall goals will be accomplished through: (a) management and coordination of program activities; (b) oversight of administrative requirements (e.g., coordination of IRB review and procedures for obtaining informed consents); (c) provision of statistical consultation to program investigators; (d) tracking of adverse events and developing necessary reports to oversight groups (e.g., IRBs at cooperating institutions, NIH), and (e) stimulation of productivity and dissemination of findings. An Advisory Committee will also be formed to review activities and progress and ensure that this program continues: (a) to meet its aims successfully, and (b) to retain its leadership role within this rapidly evolving field. The Committee will meet annually, and members will be available as needed should needs arise for additional advice.