International Symposium on ALPD and Cirrhosis

申请者描述(申请人提供)：本R13申请书旨在为2011-2015年间举行的第六届~第十届酒精性肝胰腺疾病与肝硬变国际研讨会征集资金。这一系列研讨会始于2006年，成功地将来自世界10~17个国家的120~200名具有前沿和互补性专业知识的研究人员聚集在一起，并产生了丰富的新合作，导致了该领域的重大进展。我们希望继续这一独特和协同的传统，以进一步促进对阿尔茨海默病和肝硬变的基础和翻译研究，以及对这些影响全球数百万人的重要疾病的全球推广。研讨会的总体具体目标仍然是：1)继续促进不同学科和国家之间的国际合作；2)分享各国现有的互补资源和专门知识，从而增加协同作用和独特的想法；3)鼓励青年研究人员在国际一级进行交流；以及4)促进向专业和非专业社区传播有助于预防和治疗疾病的新的科学和翻译信息。第六届~第八届研讨会将于2011年在日本福冈、2012年在北京、中国和2013年在印度德利举行，并已选定了组织者。每一次会议都将有一个独特的科学会议总主题和分主题。第六届会议的初步计划已围绕“从干细胞到全球健康”的主题制定，由国际咨询委员会审查，并得到主办组织日本肝病学会和日本胃肠病学会的批准。主题会议包括：ALD、肝脏和胰腺癌中的干细胞；ASH和酒精性胰腺炎中的细胞死亡调控；肝脏和胰腺纤维化的新见解；ALPD和肝硬化的新疗法；以及全球健康：酒精、吸烟和肥胖的影响。研讨会得到了NIAAA R13机制的部分支持，该机制用于支付受邀美国演讲者的旅行费用，并为年轻调查人员提供旅行奖励。主办组织为会场和会议后勤提供了匹配的支持，也为来自非美国和主办国的受邀演讲者和年轻与会者提供了匹配的支持。今后的专题讨论会将遵循这一分担财务责任的机制，这将确保具有成本效益的会议管理，而不影响科学和外联的协同成果。

DESCRIPTION (provided by applicant): This R13 application seeks support for the 6th~10th International Symposium on Alcoholic Liver and Pancreatic Disease (ALPD) and Cirrhosis to be held in 2011-2015. This series of symposia began in 2006 and has been highly successful in bringing together 120~200 investigators from 10~17 nations around the world with cutting-edge and complementary expertise and generating a wealth of new collaborations that led to major advances in the field. We wish to continue this unique and synergizing tradition to further promote basic and translational research on ALPD and cirrhosis, as well as global outreach on these important diseases which affect millions of people world-wide. Overall specific aims of the symposia remain to be: 1) to continue to promote international collaboration among different disciplines and nations; 2) to share the complementary resources and expertise available in various countries, thus adding synergy and unique ideas together; 3) to encourage young investigators to interact at an international level; and 4) to promote dissemination to professional and lay communities of new scientific and translational information which can be helpful for prevention and treatment of the diseases. The 6th~8th symposia will be held in Fukuoka, Japan in 2011, in Beijing, China in 2012, and Deli, India in 2013, and their organizers have been selected. Each will have a unique general theme and subthemes for scientific sessions. A preliminary program for the 6th meeting has been created around the theme of "From Stem Cells to Global Health", reviewed by International Advisory Committee, and approved by Japanese Society of Hepatology and Japanese Society of Gastroenterology, the hosting organizations. Thematic sessions include: Stem Cells in ALD, Liver and Pancreatic Cancer; Cell Death Regulation in ASH and Alcoholic Pancreatitis; Novel Insights into Liver and Pancreatic Fibrogenesis; New Treatments of ALPD and Cirrhosis; and Global Health: Impacts of Alcohol, Smoking, and Obesity. The symposia have been supported in part by the NIAAA's R13 mechanism to defray travel costs of invited US speakers and to provide travel awards for young investigators. The hosting organization provided a matching support for the venue and meeting logistics, but also for invited speakers and young attendees from non-US and hosting nations. Future symposia will follow this mechanism of shared financial responsibility, which will assure cost-effective meeting management without compromising the synergistic outcome for science and outreach.