Mutagenesis 2008 Gordon Research Conference

摘要 突变启动并促进多种人类疾病的进展，特别是癌症和神经退行性疾病；DNA损伤的突变修复有助于衰老。2008年戈登突变研究会议将集中讨论导致基因组不稳定的突变的分子机制。这次会议的目标是 (1)探索诱变机制的现有知识；(2)确定新的研究途径；(3)确定维持基因组完整性的治疗策略；(4)促进合作；以及(5)促进这一关键研究领域的长期发展。该计划将特别关注为维持人类基因组完整性的途径提供机械性理解的进展，重点是这些途径如何与遗传病、癌症、神经退化和衰老交叉。八个会议将讨论：(I)复制和转录受阻引起的突变，(Ii)氧化应激的后果，(Iii)重组导致的基因组不稳定，(Iv)免疫反应中的生理性突变，(V)与基因组不稳定、神经退化和早衰有关的罕见人类疾病，(Vi)低保真复制与癌症，(Vii)突变的机制，以及(Viii)错配修复：最终的保真度检查。对在各种生物学背景下至关重要的通路的分子和机械强调是为了吸引独特的研究人员受众，并推动他们未来的研究。

Abstract Mutations initiate and facilitate the progression of a multitude of human diseases, especially cancer and neurodegenerative diseases; and mutagenic repair of DNA damage contributes to aging. The 2008 Gordon Research Conference on Mutagenesis will focus on the molecular mechanisms of mutagenesis that give rise to genomic instability. The goals of this meeting are (1) to explore current knowledge of mutagenesis mechanisms; (2) to identify new avenues of investigation; (3) to define therapeutic strategies for maintenance of genomic integrity; (4) to stimulate collaborations; and (5) to foster the long-term development of this critical research area. The program will specifically focus on advances that provide mechanistic understanding of pathways that maintain the integrity of the human genome, with emphasis on how these pathways intersect genetic disease, cancer, neurodegeneration and aging. The eight sessions will consider: (i) Mutagenesis Due to Blocked Replication and Transcription, (ii) Consequences of Oxidative Stress, (iii) Recombination Induced Genomic Instability, (iv) Physiological Mutagenesis in the Immune Response, (v) Rare Human Diseases Associated with Genomic Instability, Neurodegeneration and Premature Aging, (vi) Low-fidelity Replication and Cancer, (vii) Mechanisms of Mutagenesis, and (viii) Mismatch Repair: the Final Fidelity Check. The molecular and mechanistic emphasis on pathways critical in a variety of biological contexts is designed to attract a unique audience of researchers and propel their future research.