Nanoconstructs Core

纳米结构核心将(1)开发新的纳米结构，可以与目前在CCNE中使用的纳米颗粒进行并行比较，以及(2)扩大现有纳米颗粒制剂的规模，使它们能够广泛分布。其基本原理是，目前正在测试纳米粒子，主要是因为它们是可用的；然而，仍然不清楚哪些纳米粒子最适合特定的应用，或者如何设计它们以实现最高的效果。因此，一个同时专注于设计和测试新结构的Core将大大加快每个CCNE研究项目的进度。因此，研究人员可以在早期开发中充分利用纳米结构，这将促进这一科学应用于临床阶段。 这一核心的基础设施代表了如何开发和快速测试纳米结构的新范例和模型。我们已经设计了一种阶段门控过程，在这种过程中，新结构有可能超过现有结构的能力，因为它们正在同时与相同的癌症进行比较。CCNE试点项目的反馈将促进早期阶段的比较，并将在确定、调整和分配最有效的代理时以动态方式分配资源。纳米结构核心将在治疗、诊断和成像的标准化试剂方面发挥关键作用，因为它将作为测试床的资源和CCNE开发的纳米结构的交换中心。能够提供质量受控、高度均匀的纳米颗粒探针的单一来源将促进和实现所有CCNE项目的更好集成，这将确保改善纳米癌症研究联系，并加快纳米技术在癌症临床治疗中的使用。因此，核心将以反馈和前馈的方式与项目密切合作，并将促进发展一个拥有纳米级合成以及与生物相关分子耦合的纳米材料的制造和表征方面的专业知识的本地社区。

The Nanoconstructs Core will (1) develop new nanoconstructs that can be compared side-by-side with nanoparticles currently used in the CCNE and (2) scale-up existing preparations of nanoparticles so that they can be widely distributed. The rationale is that nanoparticles are currently being tested primarily because they are available; however, it is still not obvious which nanoparticles are best-suited for a particular application or how to design them to achieve the highest efficacy. Therefore, a Core focused simultaneously on designing and testing new constructs will greatly accelerate progress in each of the CCNE research projects. Thus, researchers can take full advantage of the nanoconstructs in their eariy development, which will facilitate the application of this science into clinical stages. The infrastructure of this Core represents a new paradigm and model for how nanoconstructs should be developed and rapidly tested. We have designed a stage gating process where the new constructs have the potential to surpass the capabilities of the current ones because they are being compared at the same time against the same cancers. Comparison at the eariy stages will be facilitated by feedback from CCNE pilot projects, and resources will be allocated in a dynamic manner as the most efficacious agents are identified, scaled, and distributed. The Nanoconstructs Core will play a critical role in standardizing agents for therapeutics, diagnostics, and imaging because it will serve as a resource for test-bedding and a clearinghouse for CCNE-developed nanoconstructs. A single source that can provide quality-controlled, highly uniform nanoparticle probes will promote and enable better integration across all CCNE projects¿which will ensure improved nano-cancer research connections as well as expedite the use of nanotechnology in clinical treatments of cancer. Hence, the Core will work closely with the projects in a feed-back and feed-forward manner and will also serve to nucleate the development of a local community with expertise in nanoscale synthesis and fabrication and characterization of nanomaterials coupled to biologically relevant molecules.