INTERGRATIVE HEALTH SCIENCES CORE

综合健康科学核心(IHSC)是成功完成 在这次更新中提出的研究。IHSC的活动扩大了以往外地行动的工作范围 通过最大限度地提高项目协调和效率，在原有的P01中实现核心。这将通过以下方式实现 集中学校和社区关系、科目联系、健康数据收集和队列的所有方面 维修。拟议项目的互补性以及通过利用 所有三个项目的相同志愿者对象人口和社区空气污染采样地点均提供 巩固补充外地支助工作的共同基础。综合协调 由IHSC提供，将减少为实现以下目标所需的重复主体接触的需要 更新P01中的三个项目，建立统一高效的主题跟踪和更新系统 促进与研究对象的简化和协调互动，所有这些都是成功所必需的 队列研究。 IHSC将监督各种方案分项研究的受试者招募工作，以平衡科学 要求和研究需求，以及主题访问和必要的研究文档。IHSC将 收集研究项目所需的健康信息(包括个人计算机化访谈， 最大呼气肺活量测定法、自填式问卷和额外的遗传物质 基因/环境阵列分析)。IHSC将通过补充数据收集来协调努力 针对其他进行中项目的相同研究主题执行的活动，如离线或实时 采集呼出的一氧化氮和无创性测量颈动脉厚度。这将是 允许及时的学科互动，更好地利用有限的现场工作人员，减少学科和学校 不便之处。该核心还将促进与生物统计和数据的协调互动 管理核心是管理数据，并对学习成绩和质量提供及时反馈 保证活动。此外，IHSC将为每个项目提供一个集中联络点，并 设施核心，如SCEHSC中的分子生物学核心。最后，一种集中的方法来提供 在由一名调查员领导的单一核心监督下进行项目数据收集 对每个项目的覆盖面、对每个项目的承诺以及与每个项目的关系将提高P01整体效率。

The Integrative Health Sciences Core (IHSC) is central to the successful completion of the program of research proposed in this renewal. IHSC activities expand the previous scope of work of the Field Operations Core in the original P01 by maximizing project coordination and efficiency. This will be accomplished by centralizing all aspects of school and community relations, subject contact, health data collections and cohort maintenance. The complementary nature of the proposed projects and the synergy achieved from utilizing the same volunteer subject population and community air pollution sampling locations for all three projects provide a common basis for consolidation of complementary field support efforts. The integrative coordination provided by the IHSC will reduce the need for repetitive subject contacts required to accomplish the aims of the three projects in the renewal P01, establish a unified and efficient updating system for subject tracking and facilitate streamlined and coordinated interactions with study subjects, all of which are required for successful cohort studies. Subject recruitment for various programmatic sub-studies will be overseen by the IHSC to balance scientific requirements and research needs with subject access and necessary research documentation. The IHSC will collect health information needed in the study projects (including individual personal computerized interview, maximal exhaled spirometry, self-administered questionnaires and additional genetic material for gene/environmental array analyses). The IHSC will coordinate efforts with complementary data collection activities being performed on the same study subjects for other ongoing projects, such as the off-line or realtime collection of exhaled nitric oxide and the non-invasive measurement of carotid artery thickness. This will permit timely subject interactions, make better use of limited field staff and reduce subject and school inconveniences. The core will also facilitate coordinated interactions with the Biostatistics and Data Management Core in managing data and providing prompt feedback on study performance and quality assurance activities. Additionally, the IHSC will provide a centralized contact point for each of the projects and facility cores such as the Molecular Biology Core in the SCEHSC. Finally, a centralized approach to providing for project data collection under the oversight of a single core led by one investigator with over-arching coverage of, commitments to and relationships with each of the projects will improve overall P01 efficiency.