Evaluation of Dengue Epidemiology, Outcomes and Prevention in Sentinel Surveillan

描述（由申请人提供）：公共卫生相关性：登革热是一种通过蚊子叮咬传播的急性发热病毒性疾病，由四种密切相关的登革热病毒引起。据报告，在过去三十年中，登革热病例增加了四倍以上。这种疾病通常是自我限制的，尽管它可能使人丧失行为能力并需要住院治疗。严重的疾病是罕见的，但如果没有适当、及时的治疗，可能会致命。疾病预防控制中心在庞塞建立了一个哨点加强监测和研究站，使我们能够更好地了解登革热的临床过程，并更多地了解其在波多黎各的流行病学、结果和预防。通过这一合作协议提供资金的机会，我们将能够实施加强登革热诊断和管理（EDDAM）计划，该计划有可能扩大SEDSS以外的能力，实现登革热诊断和管理方面的创新。

DESCRIPTION (provided by applicant): PUBLIC HEALTH RELEVANCE: Dengue s an acute febrile viral disease transmitted through the bite of a mosquito and caused by four closely related dengue viruses. A greater than fourfold increase in dengue cases has been reported over the last three decades. The illness is frequently self-limiting, although it can be incapacitating and require hospitalization. Severe disease is rare, but may be fatal without proper, timely treatment. CDC has established a sentinel enhanced surveillance and research site (SEDSS) in Ponce that will allow us to better understand the clinical course of dengue and learn more about its epidemiology, outcomes and prevention in Puerto Rico. Through this cooperative agreement funding opportunity we will be able to implement the Enhanced Dengue Diagnosis and Management (EDDAM) Program, which has the potential of expanding the capacity beyond SEDSS to accomplish innovation in the diagnosis and management of dengue.