Research Training in Disability & Disabling Disorders

描述（由申请人提供）：本申请支持NIA的中期职业研究者（K24）面向患者研究奖的更新，授予Thomas Gill医学博士，他是一名老年病学专家和流行病学家，自1994年以来一直在耶鲁大学任教。在该奖项的前4年里，Gill博士一直是14名初级研究人员的主要或次要导师。在当前资助期内取得的重大成就包括高级作者（从2个增加到14个）和第一作者（从9个增加到16个）报告的数量急剧增加，Gill博士的受训者获得了8个职业发展奖项，Gill博士的第一个R01获得了MERIT奖的续期，收到了第二个R01，并扩大了Gill博士的研究计划，包括大规模临床试验。Gill博士的长期职业目标是在与残疾和残疾障碍相关的以患者为导向的研究中建立一个一流的项目。这次竞争性更新的具体目标是完成拟议的研究项目，并进一步加强和扩大Gill博士在初始资助期间成功建立的初级研究人员正式指导计划。Gill博士的指导计划旨在吸引跨学科的初级研究人员，他们正在从事与残疾和残疾障碍相关的以患者为导向的衰老研究。这包括一般的功能评估，以及高度流行的疾病特异性疾病（如关节炎、心脏病和抑郁症等）的功能后果。通过解决与流行病学和残疾预防相关的基本问题，吉尔博士的国际公认的研究项目为他大大扩展的导师项目提供了一个极好的平台，其中包括教学培训、实践研究培训和研究基础设施。耶鲁大学的环境提供了理想的环境，充满了跨学科的研究和培训项目，以培养吉尔博士，拟议的研究项目和指导计划。K24奖的成功续期将加强和扩大吉尔博士导师计划的基础设施，为他的学员积极参与大型研究项目创造新的机会，为试点研究提供资源，并促进吉尔博士持续的职业发展。吉尔博士设想在接下来的几年里，他的研究和指导计划将继续增长，最终建立一个新的残疾和残疾障碍中心。

DESCRIPTION (provided by applicant): This application supports a renewal of the Mid-career Investigator (K24) Award in Patient-Oriented Research from the NIA to Thomas Gill, MD, a geriatrician and epidemiologist who has been on the faculty at Yale since 1994. During the first 4 years of this award, Dr. Gill has been the primary or secondary mentor to 14 junior investigators. Significant accomplishments during the current funding period include a dramatic increase in the number of senior-authored (from 2 to 14) and first-authored (from 9 to 16) reports, receipt of 8 career development awards by Dr. Gill's trainees, renewal of Dr. Gill's first R01 with MERIT Award designation, receipt of a second R01, and expansion of Dr. Gill's research program to include large-scale clinical trials. Dr. Gill's long-term career objective is to build a premier program in patient-oriented research related to disability and disabling disorders. The specific aims of this competitive renewal are to complete the proposed research projects and to further strengthen and expand Dr. Gill's formal mentorship program for junior investigators, which he successfully established during the initial funding period. Dr. Gill's mentorship program is designed to attract junior investigators, across disciplines, who are pursuing patient-oriented aging research related to disability and disabling disorders. This includes functional assessment in general as well as the functional consequences of highly prevalent disease-specific conditions such as arthritis, heart disease, and depression (among others). By addressing fundamental issues related to the epidemiology and prevention of disability, Dr. Gill's internationally recognized research program provides a superb platform for his greatly expanded mentorship program, which includes didactic training, hands-on research training, and a research infrastructure. The Yale environment provides the ideal setting, replete with interdisciplinary research and training programs, to foster Dr. Gill, the proposed research projects, and the mentorship program. Successful renewal of the K24 Award will strengthen and expand the infrastructure for Dr. Gill's mentorship program, create new opportunities for his trainees to actively participate in large-scale research projects, provide resources for pilot studies, and facilitate Dr. Gill's ongoing career development. Dr. Gill envisions continued growth of his research and mentorship program over the next several years, culminating in a new Center for Disability and Disabling Disorders.