Predoctoral Training in Exercise Physiology and Aging

马里兰大学帕克分校运动学、运动生物学和老龄化项目 培养出训练有素的博士，完成博士后培训并成为富有成效的教师的历史 会员。在这个项目的前9年里，我们已经支持了18名学员，其中12名完成了博士学位 学位，5名仍在接受培训，1名在不同学科(神经科学)攻读医学/博士学位。十一 在12名毕业生中(92%)获得了国立卫生研究院的博士后研究奖学金。这12个中的7个 毕业生现在是终身教职，1人在工业界，1人是兼职教员，3人仍在工作 博士后职位。此外，我们还有3名非洲裔美国女性毕业，她们已经 美国国立卫生研究院在德克萨斯大学西南分校、维克森林大学和坦普尔大学的博士后研究奖学金。本节目 为学员提供完成高质量学位论文研究项目所需的技能 解决：1)身体成分、新陈代谢、简历和肌肉骨骼功能的年龄相关变化，以及 心血管疾病危险因素；2)运动训练引起的这些相同参数的变化；3)遗传 架构，这些参数的基线测量，它们随年龄的变化，以及它们 随着运动训练干预的变化；以及4)负责这些反应的机制 使用细胞和分子生物学方法的动物和细胞培养模型。一项重大改进 该更新培训计划的一个组成部分是翻译，学员可以借此延长他们的学习时间 从人类生理研究到动物模型和细胞培养的研究 潜在的细胞和分子机制。学员的研究可以在小学、中学、 马里兰大学医学院密切合作实验室的副导师 老年科，内分泌科，糖尿病和营养科，生理科，和 国家医学中心儿童护理学院遗传医学研究中心。实习生 完成衰老生物学基础课程；运动，简历，肌肉骨骼， 代谢、细胞和分子生物学和生理学；遗传学；生物统计学和研究设计。我们 建议继续该项目，资助6名博士前实习生完成博士学位，为期4年 拥有高质量课程的学位，以及为NIH做好准备的论文研究项目 博士后研究奖学金和一个研究项目的最终学术教员职位 专注于运动生物学和衰老。 相关性(请参阅说明)： 该项目将每年支持6名实习生完成博士学位和高质量的论文。 研究项目。长期目标是让学员做好准备，从事高水平的国立卫生研究院博士后研究 奖学金，并最终成为专注于预防方面的研究和教学的学术教员职位 与年龄相关的重大问题，如骨质疏松症、肥胖、糖尿病、高血压和心血管疾病。

The University of Maryland College Park Department of Kinesiology exercise biology and aging program has a history of producing well-trained PhDs who complete postdoctoral training and become productive faculty members. We have supported 18 trainees over the first 9 yrs of this program with 12 completing their PhD degrees, 5 still in training, and 1 pursuing an MD/PhD degree in a different discipline (neuroscience). Eleven of the 12 who graduated (92%) have gone on to NIH postdoctoral research fellowships. Seven of these 12 graduates are now in tenure-track academic positions, 1 is in industry, 1 is part-time faculty, and 3 are still in postdoctoral positions. Furthermore, we have graduated 3 African-American women who have gone on to NIH postdoctoral research fellowships at UT-Southwestern, Wake Forest, and Temple. This program provides trainees with the skills necessary for them to complete high-quality dissertation research projects addressing: 1) age-related changes in body composition, metabolic, CV, and musculoskeletal function, and CV disease risk factors; 2) exercise training-induced changes in these same parameters; 3) the genetic architecture underlying the baseline measures of these parameters, their changes with aging, and their changes with exercise training interventions; and 4) the mechanisms responsible for these responses in animal and cell culture models using cell and molecular biology methodologies. A substantial enhancement of this renewal Training Program is this translational component, whereby trainees can extend their studies from human physiological studies to investigations in animal models and cell culture to delineate the underlying cell and molecular mechanisms. Trainees' research can be conducted with Primary, Secondary, and Associate Mentors at closely collaborating laboratories at the University of Maryland School of Medicine Division of Gerontology, Division of Endocrinology, Diabetes, and Nutrition, Department of Physiology, and School of Nursing and Childrens National Medical Center Research Center for Genetic Medicine. Trainees complete coursework in the basic biology of aging; specific knowledge in exercise, CV, musculoskeletal, metabolic, cell, and molecular biology and physiology; genetics; and biostatistics and research design. We propose to continue this program to fund each of 6 predoctoral trainees for 4 yrs to complete their PhD degrees with high-quality coursework and a dissertation research project that will prepare them for an NIH postdoctoral research fellowship and an eventual academic faculty position with a research program focusing on exercise biology and aging. RELEVANCE (Seeinstructions): This program will support 6 trainees/yr to complete their PhD degrees with a high-quality dissertation research project. The long-term goal is to prepare trainees to pursue high-level NIH postdoctoralresearch fellowships and, eventually, academic faculty positions that focus on research and teaching in the prevention of such major age-associated issues as sarcopenia, obesity, diabetes, hypertension, and CV disease.