An implantable sensor for wireless measurement of interstitial pressure

描述（由申请人提供）：该项目的目标是开发一种用于测量实体肿瘤间质液压力（IFP）的可植入微型应答器。IFP是一个重要的临床参数，表明许多实体肿瘤对治疗药物的可及性。这是因为肿瘤中较高水平的IFP阻碍了药物的有效递送。除了化疗，放射治疗也可以通过增加缺氧肿瘤区域的氧分压来降低IFP。使用植入式微应答器测量IFP的能力将为评估用于降低IFP的各种药理学药物提供有价值的数据。此外，通过测量IFP，可以调整降低IFP药物的施用，以优化其疗效（例如，在IFP降低时施用化疗药物）。在拟议的研究过程中，我们将开发一种用于无线测量实体肿瘤内IFP的微型应答器。该微器件由一个电容式压力传感器和一个集成的盖顿胶囊连接到一个电感器，从而形成一个并联的LC电路，其谐振频率是间隙压力的度量。LC谐振器封装在玻璃管内（直径1.5mm，长1cm），盖顿胶囊侧暴露在组织中。由于间质液很容易进入装置，因此盖顿胶囊的存在可以精确测量植入后的IFP。

DESCRIPTION (provided by applicant): The goal of this project is to develop an implantable micro-transponder for measurement of interstitial fluid pressure (IFP) in solid tumors. IFP is an important clinical parameter indicating the accessibility of many solid tumors to therapeutic agents. This is in light of the fact that higher levels of IFP in tumors impede the efficient delivery of drugs. In addition to chemotherapy, radiation therapy can also benefit from lowering the IFP by increasing the oxygen partial pressure in hypoxic tumor regions. The ability to measure IFP using an implantable micro-transponder would provide valuable data for evaluating various pharmacological agents used to lower the IFP. In addition, by measuring the IFP, one can tailor the administration of IFP lowering drugs to optimize their efficacy (e.g., administration of the chemotherapeutic agent when the IFP is reduced). During the course of the proposed research we will develop a micro-transponder for wireless measurement of IFP inside solid tumors. The micro-device consists of a capacitive pressure sensor with an integrated Guyton capsule connected to an inductor, thus forming a parallel LC circuit whose resonant frequency is a measure of interstitial pressure. The LC resonator is packaged inside a glass tube (1.5mm in diameter and 1cm in length) with the Guyton capsule side exposed to the tissue. The presence of Guyton capsule allows accurate measurements of IFP following the implantation since interstitial fluid can easily ingress into the device. PUBLIC HEALTH RELEVANCE: The objective of this proposal is to develop an implantable micro-transponder for measurement of interstitial fluid pressure (IFP) in solid tumors. High levels of IFP impede the effective delivery of drugs to many tumors. The ability to measure IFP using an implantable micro-transponder would provide valuable data for evaluating various pharmacological agents and tailoring the administration of IFP lowering drugs to optimize their efficacy.