MR SPECTROSCOPY IN THE SIV INFECTED MACAQUE MODEL OF NEUROAIDS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 最近的临床观察表明，超过50%的艾滋病毒感染者表现出艾滋病毒相关的神经认知障碍（HAND），尽管接受抗逆转录病毒治疗。HAND的有效治疗方法的发展受到对其潜在疾病途径的不完全理解的阻碍。我们研究的目标是推进目前对HAND进展的理解，并开发有效的治疗方法来预防它。加速SIV猕猴模型产生的艾滋病与人类艾滋病非常相似，包括神经病理学变化，并作为测试HIV治疗的绝佳背景，因为进展到晚期艾滋病的过程发生在几周内，而不是几年。该模型结合磁共振波谱（MRS）和成像，免疫学，病毒学和神经病理学为神经保护和抗炎治疗前景提供了有见地的数据，并允许快速转化为人类临床试验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Recent clinical observations indicate that over 50% of HIV-infected patients manifest HIV-Associated Neurocognitive Disorders (HAND) despite receiving antiretroviral therapy. Development of effective treatments for HAND is hindered by an incomplete understanding of its underlying pathways to disease. The goal of our study is advance the current understanding of HAND progression and to develop effective treatments to prevent it. The accelerated SIV macaque model produces AIDS that is extremely comparable to the human counterpart, including neuropathological changes, and serves as an excellent backdrop for testing HIV treatments, as the course of progression to terminal AIDS occurs within several weeks instead of years. This model combined with magnetic resonance spectroscopy (MRS) and imaging, immunology, virology and neuropathology provide insightful data into neuroprotective and anti-inflammatory treatment prospects and allows for rapid translation to human clinical trials.