课题基金 / 基金详情

Allergen and T-Cell Reagent Resources for the Study of Allergic Diseases

Allergen and T-Cell Reagent Resources for the Study of Allergic Diseases
用于过敏性疾病研究的过敏原和 T 细胞试剂资源
批准号：
8317525
负责人：
William W. Kwok
金额：
$218.94万
依托单位：
BENAROYA RESEARCH INST AT VIRGINIA MASON
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
项目状态：
已结题
起止时间：
2007-09-28 至 2012-09-27
来源：
https://reporter.nih.gov/project-details/8317525
关键词：
AffinityAlder plantAllergensAllergic DiseaseAllergic rhinitisAsthmaBetula GenusBindingCD4 Positive T LymphocytesCell LineContractorCore FacilityCynodonDiseaseEpitopesFelis catusFood HypersensitivityFrequenciesGoalsMHC Class II GenesMethodsPeanuts - dietaryPeptidesPhenotypePhleumReagentRegulatory T-LymphocyteResearchResourcesSourceSupport ContractsT-LymphocyteT-Lymphocyte EpitopesTechniquesVenomsYellow Jacketsanergycytokinefungusinnovationnovelvaccine development

项目摘要

项目成果

William W. Kwok的其他基金

相关文献

中文摘要
翻译
该合同支持两个不同的目标。第一个目标是支持核心设施，这些设施将使用创新的分离和纯化技术，从各种来源鉴定与过敏性疾病（包括哮喘和过敏性鼻炎）相关的新型过敏原。第二个目标是鉴定和表征含有T细胞表位的肽，所述T细胞表位诱导过敏原特异性效应T细胞中的无反应性，或激活过敏原特异性调节性T细胞。该计划的主要目标是使用创新的纯化方法鉴定新的过敏原，并产生一组定义的肽，调节过敏原特异性效应细胞和调节性T细胞的功能。
英文摘要
This contract supports two distinct objectives. The first objective is to support core facilities that will use innovative isolation and purification techniques to identify novel allergens associated with allergic diseases including asthma and allergic rhinitis, from various sources. The second objective is to identify and characterize peptides containing T cell epitopes that induce anergy in allergen-specific effector T cells, or activate allergen-specific regulatory T cells. The major goals of this initiative are to identify novel allergens using innovative purification methods, and to generate a set of defined peptides that regulate the function of allergen-specific effector and regulatory T cells.
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Core-001
Allergen T cell epitopes and phenotypes in peanut allergy
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Antigen specific T cell responses to two different strains of SARS-CoV-2