Mathematics Core

这一建议的基础是对癌症的数学和实验观察的整合。作为一名 结果，数学专业知识分布在每个组件中。支持和扩展 应用集成数学肿瘤学，我们将形成一个计算/数学核心，将服务于 研究项目以及PS-OC的教育和推广部分 以下是： 1.提供先进的计算技术、方法和专业知识。 2.生态学和进化生物学及相关数学模型方面的专门知识 3.促进PS-OC成员之间以及与实验者、临床医生、 数学家、物理学家和其他希望使用或了解更多集成知识的科学家 数学肿瘤学。 核心将购买和维护先进的计算基础设施，供 PS-OC成员，用于计算要求苛刻的项目。它将聘请一名计算机科学家来维护 设施，并协助会员使用。 由于体细胞进化是原位癌和浸润性癌许多动态变化的来源， CORE将通过以下方面的专家顾问向PS-OC提供丹威动力学方面的专业知识 生态学和进化论原理以及在广泛应用进化模型方面的经验 包括癌症在内的生物系统。 最后，核心将通过采用

The basis of this proposal is integration of mathematics and experimental observations in cancer. As a result, mathematical expertise is distributed throughout every component. To support and expand the application integrated mathematical oncology, we will form a computational/mathematical core that will serve the research projects as well as the educational and outreach component of the PS-OC through the following: 1. Provide advanced computational technology, methods, and expertise. 2. Expertise in ecology and evolutionary biology and associated mathematical models 3. Facilitate collaborations among members of the PS-OC and with experimentalists, clinicians, mathematicians, physicists and other scientists who wish to use or learn more about integrated mathematical oncology. The core will purchase and maintain an advanced computing infrastructure that will be available to the members of the PS-OC for computationally demanding projects. It will hire a computer scientist to maintain the facility and assist members with its utilization. Since somatic evolution is the source of many of the dynamical changes in both in-situ and invasive cancer, he core will provide expertise in Danwinian dynamics to the PS-OC through consultants who are experts in the principles of ecology and evolution and experienced in application of evolutionary models to a wide range of biological systems including cancer. Finally, the core will encourage new collaborations by employing a