Mood, Physiological Arousal, and Alcohol Use

描述（由申请人提供）：本项目将实时研究情绪、自主神经超唤醒和酒精使用之间的关系，并确定实验室中对标准刺激的自主神经超唤醒反应是否与日常生活中的情绪-酒精关系有关。方法采用动态生理和自我报告评估，情绪调节困难（即符合边缘性人格障碍标准）和社区控制的参与者将在一周内提供有关情绪和饮酒的信息。自主神经超反应性也将在实验室进行评估，以便为实时数据提供比较。该项目的结果将为酒精使用的负强化模型提供信息，并有助于确定酒精使用障碍的生理内表型。培训目标奖学金申请人将学习自主神经系统功能，心理生理学数据分析，密集纵向数据分析，并将获得在适当的科学期刊上发表本研究结果的经验。这将为申请人的职业生涯做好准备，使用转化研究来研究酒精使用的生理和情感风险因素。

DESCRIPTION (provided by applicant): This project will examine the relation between mood, autonomic hyper-arousal, and alcohol use in real-time, and determine whether autonomic hyper-arousal responses to standard stimuli in the laboratory are related to affect-alcohol relations in daily life. Method Using ambulatory physiological and self-report assessments, participants with difficulties in emotion regulation (i.e., meet criteria for borderline personalit disorder) and community controls will provide information regarding mood and drinking over the course of a week. Autonomic hyper-reactivity will also be assessed in the laboratory, in order to provide a comparison for real-time data. Long-Term Objectives Results from this project will inform negative reinforcement models of alcohol use and help identify physiological endophenotypes for alcohol use disorders. Training Aims The fellowship applicant will learn about autonomic nervous system functioning, analysis of psychophysiological data, analysis of intensive longitudinal data, and will gain experience communicating findings from this study in appropriate scientific journals. This will prepare the applicant for a career using translational research to study physiological and affective risk factors for alcohol use. PUBLIC HEALTH RELEVANCE: The proposed project will help identify subjective and autonomic factors that increase risk for alcohol-related problems. Thus, this project may influence preventative and intervention efforts by educating the public regarding specific emotional and autonomic states that may lead to alcohol abuse. With increased awareness of specific risk factors, individuals can make better behavioral decisions regarding alcohol use.