The treatment of childhood obesity

描述（由申请人提供）：这是一份独立科学家奖（KO2）的提案，旨在扩大申请人在青少年肥胖行为干预方面的研究项目，以预防心血管危险因素和疾病。在肥胖治疗和维持减肥方面的有限进展表明，应重点改进当前的治疗方法，并将基础行为科学转化为临床研究。本应用的目的是通过专业合作和高级培训，开发一种多层次的方法来研究青少年肥胖的行为治疗。本申请概述的三个职业目标是：1)获得进一步的知识和经验，为青少年肥胖治疗领域做出实质性贡献；2)努力优化目前可用的儿童肥胖治疗方法，并为临床创造这些治疗方法的可翻译版本；3)为超重和肥胖儿童的治疗确定高度新颖的目标。基于基础行为科学和神经科学的发现。职业发展活动包括与从事基础行为科学和神经科学工作的同事进行磋商、正式课程学习、实践培训以及与神经成像专家合作。对这一应用程序的支持将使PI有更多的时间专注于研究和开发基础行为科学知识以及对肥胖和暴饮暴食的神经生物学理解。该应用程序将使Boutelle博士获得知识，进行富有成效的转化研究，以改善和发展肥胖干预措施，并最大限度地发挥她对该领域的贡献。

DESCRIPTION (provided by applicant): This is a proposal for an Independent Scientist Award (KO2) to expand the applicant's research program on behavioral interventions for obesity in youth, to prevent cardiovascular risk factors and disease Limited progress in obesity treatment and maintenance of weight loss argues for a focus on improving current treatments and for translating basic behavioral science to clinical research. The aim of this application is t develop a multilevel approach for studying behavioral treatments for obesity in youth by pursuing specialized collaborations and advanced training. The three career goals outlined in this application are 1) To gain further knowledge and experiences to substantially contribute to the field of the treatment of obesity in youth, 2) To work toward optimizing currently available approaches for child obesity treatment, and to create translatable versions of these treatments for the clinic and 3) To identify highly novel targets for the treatment of children who are overweight and obese, based on findings from basic behavioral sciences and on neuroscience. Career development activities include consultations with colleagues working in basic behavioral sciences and neuroscience, and formal course work, hands-on training, and collaboration with experts in neuroimaging. Support of this application will allow the PI the much needed time to focus on research and develop a base of basic behavioral sciences knowledge and neurobiological understanding of obesity and overeating. This application will allow Dr. Boutelle to gain the knowledge to conduct productive translational research to improve and develop obesity interventions, and maximize her contributions to the field. PUBLIC HEALTH RELEVANCE: The purpose of this application is to support protected research time for Dr. Boutelle to gain further knowledge and experiences that will allow her to significantly contribute to the field of child obesity treatment.