2012 Gordon Conference on Molecular Mechanisms in Lymphatic Function and Disease

描述（由申请人提供）：本申请是为第五届戈登淋巴功能和疾病分子机制研究会议提供部分支持，该会议将于2012年3月4日至9日在加利福尼亚州文图拉的文图拉海滩万豪酒店举行。该会议自2002年以来每两年举行一次，由戈登研究会议组织，该组织以其高质量，尖端的会议性质而闻名于世。虽然这是一个相对年轻的GRC会议，但自十多年前成立以来，出席会议的人数一直在稳步增长。虽然在历史上被忽视，淋巴生物学主题的研究在过去10年里经历了戏剧性的增长，这在很大程度上是因为淋巴生长的关键调节因子的确定和有价值的动物模型的产生。直到最近，淋巴血管系统的功能作用一直只与脂质吸收、体液平衡和免疫监视有关，而淋巴血管功能障碍与症状性病理状况（如淋巴水肿）有关。过去几年的研究工作使人们对血管系统在健康和疾病中的功能作用有了更好的了解。此外，最近的研究还揭示了淋巴血管在脂肪代谢、肥胖、炎症和高血压患者盐储存调节中的其他功能作用。因此，淋巴生物学家、癌症研究人员、生理学家、生物医学工程师和医生空前需要有一个论坛，在这个论坛上围绕这一领域的科学发展进行广泛的对话，并确定未来基础和临床研究工作的方向。新一代淋巴研究的研究领域包括但不限于遗传学、生物化学和生理学、细胞和分子生物学、免疫学、癌症研究、心血管医学、生物工程、体内成像和药理学。举个例子，PubMed上有1517篇关于淋巴管生成的文章，其中三分之一是最近几年发表的。这使得人们对疾病有了新的认识

DESCRIPTION (provided by applicant): This application is for partial support of the fifth Gordon Research Conference on Molecular Mechanisms in Lymphatic Function and Disease to be held in Ventura Beach Marriott in Ventura, California, between March 4-9, 2012. This conference has been held every two years since 2002 and is organized by the Gordon Research Conferences, an organization internationally known for the high quality, cutting edge nature of its meetings. Although a comparatively young GRC conference, attendance at the meeting has grown steadily since its inception over ten years ago. While historically neglected, research in the topics of lymphatic biology have experienced a dramatic growth within the last 10 years, in large part because the identification of critical regulators of lymphatic growth and the generation of valuable animal models. Until recently, the functional role of the lymphatic vascular system has been exclusively associated with lipid absorption, fluid homeostasis, and immune surveillance and lymphatic vessel dysfunction had been associated with symptomatic pathologic conditions such as lymphedema. Work in the last few years had led to a better understanding of the functional roles of this vascular system in health and disease. Furthermore, recent work has also unraveled additional functional roles of the lymphatic vasculature in fat metabolism, obesity, inflammation, and the regulation of salt storage in hypertension. Therefore, there is an unprecedented need for lymphatic biologists, cancer researchers, physiologists, biomedical engineers and physicians to have a forum in which to conduct a broad dialogue surrounding scientific developments in this field and to determine the direction of future basic and clinically- oriented investigative efforts. Lines of investigation tht have experienced a recent upsurge in next generation lymphatic investigation include, but are not limited to genetics, biochemistry and physiology, cellular and molecular biology, immunology, cancer research, cardiovascular medicine, bioengineering, in vivo imaging and pharmacology. As an example, there are 1517 postings on lymphangiogenesis on PubMed, with a third of those published in the last couple of years. This has lead to new insights into diseases such as cancer, cardiovascular diseases, chronic inflammation and lymphedema (both congenital and surgery-induced). The new lymphatic field finds applications in broad areas of pathology, inflammation, cardiovascular and tumor biology with new efforts for clinical translation. This meeting will bring together the leading basic and clinically oriented experts in the field of lymphatic biology and is expected to provide new insights into the mechanisms of disease and to promote the development of new therapeutic strategies.