Neuroimaging Core Facility

GCAP神经成像核心实施质量控制程序，优化和更新成像协议，从CBDB兄弟和住院研究中收集所有临床成像数据，并维护和分析这些研究中使用的所有结构、光谱、DTI和大规模档案fMRI数据。 神经成像核心涵盖以下神经成像领域： 1.结构磁共振成像：采集、质量控制、分割、自动和手动感兴趣区域(ROI)定义和测量、表面提取； 2.功能磁共振成像：采集、质量控制、前处理、标准化分析； 3.光谱学：采集、质量控制、预处理、基于感兴趣区和体素； 4.DTI：采集、质量控制、前处理； 5.实施新的磁共振成像技术。 神经成像核心具有以下功能： 1.医疗覆盖和图像采集、图像质量控制(针对核心采集的数据)； 2.刺激设备的维护，与其他NIH成像核心设施的联系； 3.实施和维持生理测量和干预措施(如皮肤电反应、瞳孔测量、脉压)； 4.创建和更新MR采集和数据分析方法手册； 5.对研究助理和研究员进行神经成像方法和分析的培训和监督； 6.进行标准化分析和分析质量控制；以及 7.数据挖掘和将原始数据和处理后的数据分发给GCAP调查员；与GCAP内维护的基因组数据和其他科学数据相结合。 预计GCAP执行的其他成像研究可能会对其可以执行的部分(如结构磁共振扫描)使用神经成像核心协议和设施，以促进将这些数据与更大的档案数据集整合和关联。 为了在临床上发挥作用，核心需要几名内科医生的参与来执行数据挖掘和分析功能；需要计算机专家和相当大的研究助理小组，他们在成像和图像分析之间轮换，并接受培训以保持成像和分析方面的标准知识水平。核心的日常运作由神经成像核心主管监督。 神经成像核心公司的战略和监督由基因、认知和精神病计划主任以及一个由临床研究人员和临床和科学主任组成的小组领导。

The GCAP Neuroimaging Core implements quality control procedures, optimizes and updates imaging protocols, and collects all clinical imaging data from the CBDB sibling and inpatient studies, and maintains and analyzes all structural, spectroscopy, DTI, and large scale archival fMRI data used in these studies. The Neuroimaging Core covers the following neuroimaging domains: 1. Structural MRI: acquisition, quality control, segmentation, automated and manual regions-of-interest (ROI) definition and measurements, surface extraction; 2. Functional MRI: acquisition, quality control, preprocessing, standardized analyses; 3. Spectroscopy: acquisition, quality control, preprocessing, ROI-based and voxel-based; 4. DTI: acquisition, quality control, preprocessing; 5. Implementing new MRI techniques. The Neuroimaging Core subserves the following functions: 1. Medical coverage and image acquisition, image quality control (for data acquired by the core); 2. Maintenance of stimulation equipment, liaison with other NIH imaging core facilities; 3. Implementing and maintaining acquisition of physiological measurements and interventions, (e.g. galvanic skin response, pupillometry, pulse pressure); 4. Creates and updates a manual of MR acquisition and data analysis methods; 5. Training and supervising of research assistants and fellows in neuroimaging methods and analysis; 6. Perform standardized analyses and analysis quality control; and 7. Data mining and distributing of raw and processed data to GCAP investigators; integration with genomic and other scientific data maintained within GCAP. It is expected that other imaging studies performed in GCAP may use the Neuroimaging Core protocols and facilities for those parts (such as structural MRI scanning) it can perform to facilitate integrating and relating these data to the larger archival datasets. To function clinically, the core requires the participation of several staff physicians to perform data mining and analysis functions; requires computer specialists, and a fairly large group of research assistants who rotate between imaging and image analyses and are trained to maintain a standard level of knowledge in imaging and analysis. Day-to-day operation of the core is overseen by the Director of the Neuroimaging Core. Neuroimaging Core's strategy and supervision is under the direction of the Director of the Genes, Cognition and Psychosis Program and a panel consisting of clinical investigators and the Clinical and Scientific Directors.