Nanotechnology Based Infection Control for Ventricular Assist Devices

描述（由申请人提供）：在过去的五十年中，全人工心脏技术的感染和血栓控制一直是人们关注的焦点。即使是完全植入的全人工心脏，感染控制也是必要的，因为患者仍然需要经皮穿刺来收集植入后的血流动力学数据。在与NIH/NHLBI的第一阶段合同中，ND Life和匹兹堡大学开发了一种基于纳米技术的高效抗感染涂层系统，可以很容易地应用于心室辅助装置（vad）传动系统的治疗。在第一期研究中，研究人员探索了一种新的绿色处理技术，将银纳米颗粒固定在涤纶上。在第二期研究中，不可逆地将银纳米颗粒固定在涤纶上，可以显著减少细菌的挑战。在第二期研究中，ND Life和匹兹堡大学将通过一种新的绿色处理技术，通过体外和体内研究来优化基于纳米技术的抗菌涂层系统。我们在这里提出的系统将为VAD传动系统提供一种简单而高效的抗感染涂层技术，并与广泛的其他植入式医疗设备相关。

DESCRIPTION (provided by applicant): Control of infection and thrombosis in total artificial heart technology has been of great concern for the last five decades. Even for totally implantable total artificial hearts, infection control is necessary because patients still need percutaneous lines for collecting post-implant hemodynamic data. During the Phase I contract with NIH/NHLBI, ND Life and University of Pittsburgh developed a highly effective anti-infection coating system based on nanotechnology that can be easily applied to the treatment of drivelines for ventricular assist devices (VADs). A novel green processing technique has been explored to immobilize silver nanoparticles on Dacron in Phase I. Irreversibly immobilized silver nanoparticles on Dacron showed significant reduction of bacterial challenges in Phase I. In the Phase II, ND Life and University of Pittsburgh will optimize the nanotechnology-based antimicrobial coating systems by a novel green processing technique through in vitro and in vivo studies. The system we propose here will provide a simple and highly effective anti-infection coating technology for VAD drivelines, with relevance to a broad range of other implantable medical devices. PUBLIC HEALTH RELEVANCE: The technology to be developed in Phase II will result in a simple and highly effective anti- infection coating technology for a broad range of implantable medical devices in addition to drivelines for VADs. Some specific areas that would utilize this technology would include catheters, medical bandages, bandages for burn and wound treatments, membranes for respiratory systems, cuffs for ancillary ports for dialysis, chemotherapy etc., membranes for water purification, and membranes for air purification.