Training in Respiratory Biology: Innovate, Integrate, and Translate

描述（由申请人提供）：我们的目标是培养下一代专注于呼吸系统疾病的生物医学科学家。由加州大学圣地亚哥分校（UCSD）肺重症监护（PCCM）和生理学部门领导的该培训计划的教师准备将医学博士和博士候选人培养成医学科学家，他们将促进我们对肺部疾病和呼吸生物学的理解。我们在一个多学科培训计划中专注于三个科学主题：气道炎症和免疫学，肺血管生物学和缺氧与睡眠。这三个科学主题都将强调创新的原则。我们的培训环境和教育活动旨在通过强调对关键研究问题的多学科方法来激发科学创造力。受训者将从几个科室和部门中选择在肺部医学和生物医学科学方面具有广泛专业知识的导师，在那里他们将接触到最前沿的思想和方案。整合与一个成功的项目密切相关，在这个项目中，受训者将跨越基础科学和临床科学的传统学科的界限。受训者将专注于高整合可能性的三个主题之一的研究。气道炎症和免疫学，肺血管生物学，缺氧和睡眠的主题是现代呼吸生物学和肺部医学研究的核心，并且这些主题在UCSD通过在这些领域具有国际声誉的实验室之间的正式和非正式合作紧密联系在一起。将基础科学发现转化为临床实践是我们项目的核心。例如，进入该项目的博士将参加基础科学教学课程，以优化他们的科学背景。我们还利用UCSD独特的转化项目，如由霍华德休斯医学研究所（HHMI）资助的UCSD博士研究生“医学到研究生”项目。在博士后阶段，对流行病学和生物统计学方面的进一步正规教育感兴趣的学员有机会通过UCSD临床研究增强补充培训（CREST）计划参加患者和基于人群的临床研究补充课程。在某些情况下，感兴趣的学员将通过圣地亚哥州立大学公共卫生研究生院攻读流行病学或生物统计学公共卫生硕士学位。

DESCRIPTION (provided by applicant): Our goal is to train the next generation of biomedical scientists focused on respiratory disorders. The faculty in this training program, led by the University of California San Diego (UCSD) Pulmonary Critical Care (PCCM) and Physiology Divisions, are prepared to train and transform MD and PhD candidates into medical scientists who will advance our understanding of lung disease and respiratory biology. We have focused on three scientific themes in a multidisciplinary training program: Airway Inflammation and Immunology, Pulmonary Vascular Biology and Hypoxia and Sleep. All three scientific themes will stress the principle of innovation. Our training environment and educational activities are designed to stimulate scientific creativity by emphasizing a multidisciplinary approach to crucial research questions. Trainees will choose mentors from several Divisions and Departments with a wide range of expertise in pulmonary medicine and biomedical sciences where they will be exposed to cutting edge ideas and protocols. Integration is germane to a successful program where trainees will work across the boundaries of traditional disciplines in basic and clinical science. Trainees will focus on research in one of the three themes selected for high probability of integration. The themes of Airway Inflammation and Immunology, Pulmonary Vascular Biology, and Hypoxia and Sleep are central to modern respiratory biology and pulmonary medicine research plus they are strongly linked at UCSD by both formal and informal collaborations between laboratories with international reputations in these areas. Translation of basic science discoveries to clinical practice is at the core of our program. For example, MDs who enter the program will participate in basic science didactic sessions to optimize their scientific background. We also take advantage of unique translational programs at UCSD such as the "Med into Grad" program for Ph.D. students funded at UCSD by the Howard Hughes Medical Institute (HHMI). At the postdoctoral level, trainees with interest in further formal education in epidemiology and biostatistics beyond that provided by this training grant have the opportunity to take supplemental courses in patient and population-based clinical research through the UCSD Clinical Research Enhancement through Supplemental Training (CREST) program. In some cases, interested trainees will work towards completion of a Master's in Public Health in epidemiology or biostatistics through the San Diego State University Graduate School of Public Health.