Training In Drug Abuse and Brain Imaging

描述（由申请人提供）：随着多模式神经成像的广度和深度迅速扩大，非常需要培训个人如何使用该技术来更好地检测，理解，开发新药，跟踪和预防药物滥用。先进的MRI、PET、EEG和近红外光谱（NIRS）技术可用于探索药物滥用和依赖的神经生物学基础。这是一个建议，继续T32机构博士后培训计划，以填补在该领域的重要培训需求。该培训计划的主要内容包括：两个地点（麦克莱恩医院和MGH）;从基础科学到临床治疗单位的多个部门的参与;在几种成像模式（包括MR，PET，EEG，NIRS）中的培训的可用性;临床和临床前培训机会与综合转化研究机会; NIH资助的项目的丰富广度，以支持学员的研究;一群经验丰富的导师，他们在过去的9年里一直在一起工作;四个明确的培训轨道选项，包括：1）技术和仪器，2）临床基础，3）临床治疗和4）翻译;精心设计的2 - 3年培训计划，整合课程作业，负责任的研究行为，实验室轮换，论文和赠款写作经验和独立研究;学员在从该计划毕业后获得独立资助的成功记录;学员出版物的成功率;以及对该计划的广泛机构支持，这一点从我们的3T和4T临床扫描仪的重大升级以及9.4T动物扫描仪的增加中得到了证明。在过去的9年里，我们已经开发和维护了一个综合的，多学科的药物滥用和脑成像培训计划（DABITP），目前支持4个博士后职位;我们建议将受训人员的数量增加到六个名额，因为该计划一直是满的，我们已经扩大到包括马蒂诺斯生物医学成像中心（在MGH），它为该项目带来了MR-PET成像培训，并在麦克莱恩医院建立了四个新的培训实验室。脑成像和精神药理学的教学培训与各种非常成功的研究实验室的实际应用相结合，为我们的学员提供了在未来十年研究成瘾大脑时利用广泛的脑成像技术的技能。 公共卫生相关性：先进的脑成像技术更频繁地被用于更好地检测，理解，开发新药，跟踪和预防药物滥用。在过去的9年里，我们建立并维护了一个综合的，多学科的药物滥用和脑成像培训计划（DABITP），目前支持4个博士后职位，以培训个人如何将成像技术与药物滥用的基础和应用临床研究和转化模型相结合，以满足这些重要需求。导师的证书的广泛广度为学员提供了学习应用这些技能的最佳机会，以进一步了解成瘾大脑的神经生物学基础。

DESCRIPTION (provided by applicant): As the breadth and depth of multimodal neuroimaging rapidly expands, there is an important need to train individuals on how use the technology to better detect, understand, develop new medications, track and prevent drug abuse. Sophisticated MRI, PET, EEG and Near Infrared Spectroscopy (NIRS) techniques can be used to explore the neurobiological bases of drug abuse and dependence. This is a proposal to continue a T32 Institutional postdoctoral Training Program to fill an important training need in the field. The key elements of this Training Program include: two locations (McLean Hospital and MGH); participation by multiple departments from basic science to clinical treatment units; availability of training in several imaging modalities including MR, PET, EEG, NIRS; clinical and preclinical training opportunities with integrated translational research opportunities; rich breadh of NIH funded projects to support the trainees' research; group of well-seasoned mentors who have been working together for the past 9 years of this program; option of four well-defined training tracks including: 1) Technology & Instrumentation, 2) Clinical-Basic, 3) Clinical-Treatment and 4) Translational; well-designed 2-3 year training plans that integrate coursework, responsible conduct of research, lab rotations, paper & grant writing experience and independent research; very successful track record of trainees' securing independent funding upon graduation from the program; successful rate of trainee publications; and extensive institutional support for the program as evidenced by significant upgrades to our 3T and 4T clinical scanners and the addition of a 9.4T animal scanner. Over the past 9 years we have developed and maintained an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program (DABITP) that currently supports 4 postdoctoral slots; we propose to increase the number of trainees to six slots because the program is consistently full and we have expanded to include the Martinos Center for Biomedical Imaging (at MGH), which brings combined MR-PET imaging training to the program and four new training laboratories at McLean Hospital. The combination of didactic training in brain imaging and psychopharmacology with practical applications in a variety of highly successful research laboratories provides our trainees with the skills to utilize a broad range of brain imaging techniques as they embark on the next decade of research on the addicted brain. PUBLIC HEALTH RELEVANCE: Sophisticated brain imaging techniques are more frequently being used to better detect, understand, develop new medications, track and prevent drug abuse. Over the past 9 years we have built and maintained an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program (DABITP) that currently supports 4 postdoctoral slots to train individuals how to merge imaging technologies with basic and applied clinical research and translational models of drug abuse in order to meet these important needs. The extensive breadth of credentials of the mentors offers the trainees the best opportunity to learn to apply these skills in order to further our understanding of the neurobiological bases of the addicted brain.