DIET AND GENOTYPE IN PRIMATE ATHEROSCLEROSIS: DATA MANAGEMENT AND COMPUTING

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 数据管理和计算核心（CORE UNIT B）1）将为项目提供数据库管理服务，这些项目将在计划项目中生成和分析表型、基因型和基因表达数据，2）还将为拟议的研究工作提供高通量分析计算支持。Core B将确保数据质量控制，支持应用软件，为本计划项目中使用的计算机提供网络和系统管理，并保护项目数据的安全。 在拟议的资助期间，该核心的具体目标是：1）根据系谱关系，协助、促进和验证拟议研究项目的特定动物选择; 2）管理本计划项目中使用的计算机化数据的获取、输入和控制; 3）管理实验室间的文件传输; 4）处理实验室数据并维护用于处理的软件; 5）控制收集的数据的质量; 6）将原始数据转换为适合遗传分析的形式; 7）保护收集的数据的安全性/完整性; 8）根据需要进一步开发和增强本计划项目中使用的软件; 9）根据需要承担系统编程任务，以维护计算机系统及其通信网络; 10）为数据和系统文件提供备份; 11）保护本计划项目中使用的计算机的安全;和12）为四个相关科学项目所需的高通量分析提供最先进的计算支持。 该核心小组支持的四个拟议研究项目代表了二十多年来对纯种狒狒模型研究的自然延伸。除了管理和处理在拟议的资助期间收集的数据外，核心B也是过去建立、管理和描述大型狒狒谱系以及检测和定位动脉粥样硬化风险因素变异基因的努力之间连续性的重要来源。核心B的拟议努力将有助于利用从这些相同的扩展谱系的狒狒中获得的数据来鉴定和分析基因的功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Data Management and Computing Core (CORE UNIT B) 1) will provide database management services to the projects which will be generating and analyzing phenotypic, genotypic, and gene expression data within the Program Project and 2) will also provide high-throughput analytical computational support to the research efforts proposed. Core B will ensure data quality control, support applications oftware, provide network and systems management for computers used in this Program Project, and protect the security of project data. Specific aims of this core during the proposed grant period are 1) to assist, facilitate, and validate -- based on pedigree relationships -- the selection of specific animals for the proposed research projects; 2) to manage acquisition, entry, and control of computerized data used in this Program Project; 3) to manage inter-laboratory file transfer; 4) to process laboratory data and maintain the software used for processing; 5) to control the quality of the data collected; 6) to transform raw data into forms suitable for genetic analysis; 7) to protect the security/integrity of collected data; 8) to further develop and enhance software used in this Program Project as needed; 9) to undertake systems programming tasks as needed to maintain the computer system and its communications network; 10) to provide backup for data and systems files; 11) to protect the security of the computers used in this Program Project; and 12) to provide state-of-the-art computational support for the high-throughput analyses required in the four associated scientific projects. The four proposed research projects supported by this Core Unit represent the natural extension of more than two decades of research with the pedigreed baboon model. In addition to the management and processing of the data collected during the proposed funding period, Core B is also an important source of continuity between past efforts to establish, manage, and characterize the large baboon pedigrees, and detect and localize genes responsible for variation in atherosclerosis risk factors. The proposed efforts of Core B will contribute to identification and analysis of function of genes with data obtained from baboons from these same extended pedigrees.