DATA MANAGEMENT AND COMPUTING

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is Core B of the Program Project "Diet and Genotype in Primate Atherosclerosis." The Data Management and Computing Core 1 provides 1) database management services to the projects within the larger baboon program project which generate and analyze phenotypic, genotypic, and gene expression data within the Program Project and 2) high-throughput analytical computational support to their research efforts. Core B ensures data quality control, supports applications software, provides network and systems management for computers used in this Program Project, and protects the security of project data. The specific aims of this core during the proposed grant period are 1) to assist, facilitate, and validate -- based on pedigree relationships -- the selection of specific animals for the proposed research projects; 2) to manage acquisition, entry, and control of computerized data used in this Program Project; 3) to manage inter-laboratory file transfer; 4) to process laboratory data and maintain the software used for processing; 5) to control the quality of the data collected; 6) to transform raw data into forms suitable for genetic analysis; 7) to protect the security/integrity of collected data; 8) to further develop and enhance software used in this Program Project as needed; 9) to undertake systems programming tasks as needed to maintain the computer system and its communications network; 10) to provide backup for data and systems files; 11) to protect the security of the computers used in this Program Project; and 12) to provide state-of-the-art computational support for the high-throughput analyses required in the four associated scientific projects. The three research projects supported by this Core Unit represent the natural extension of more than two decades of research with the pedigreed baboon model. In addition to the management and processing of the data collected during the proposed funding period, Core B is also an important source of continuity between past efforts to establish, manage, and characterize the large baboon pedigrees, and detect and localize genes responsible for variation in atherosclerosis risk factors. Core B has been instrumental in the development and improvement of the baboon whole genome linkage map and in the development and maintenance of a whole genome transcriptional profile database for more than 47,000 human transcripts assayed in the lymphocytes of 500 baboons. The efforts of Core B personnel contribute to identification and analysis of function of genes with data obtained from baboons from these same extended pedigrees by investigators from this program project, as well as in other studies by investigators from SFBR and other institutions.