NOVEL GABA(A) MODULATORS AS COGNITIVE ENHANCERS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 阿尔茨海默病是一种慢性、进行性和最终致命的神经退行性疾病，目前几乎没有广泛有效的治疗选择。 这项应用的总体目标是探索新化合物的潜力，作用于称为“GABA受体”的大脑蛋白质，以增强认知功能。 由于这些化合物似乎非常安全，它们可能为治疗与阿尔茨海默氏症和其他相关疾病相关的记忆衰退提供一种有希望的新方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Alzheimer's disease is a chronic, progressive, and ultimately fatal neurodegenerative disease, and there currently are few broadly effective treatment options. The overall goal of this application is to explore the potential for new compounds, acting at a brain protein called the "GABA receptor", to enhance cognitive function. Because these compounds appear to be remarkably safe, they may provide a promising new approach for treating memory decline associated with Alzheimer's and other related disorders.