COBRE: UNE MED CTR: CORE C: HISTOLOGY CORE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 组织学核心的使命是为COBRE计划的研究人员提供服务，满足他们对感觉神经发育和相关小鼠表型的专门形态学和组织学分析的需求。组织学核心设施为COBRE研究人员和组织学研究人员提供了几个优势。 COBRE计划：（1）丰富资源：设立配备专家人员的核心设施，将为各个研究人员提供其各自实验室无法随时提供的多种服务、设备资源和技术专门知识。这将大大拓宽个别研究项目的深度，并支持发展最先进的技术， 在个别初级研究人员的实验室内进行全面的研究计划。2)人员和成本管理的效率：将此类资源集中在核心内允许在使用通常昂贵的试剂（例如，专用试剂）时实现更好的效率和标准化。 抗体的此外，联合国监测委员会表型鉴定处处长M. Anita Jennings将减少每个PI将其人员分配到需要大量培训和时间才能熟练执行的方法的需要。此外该 使用通用试剂可让来自不同实验室的研究人员更好地比较和解释结果。3)质量保证、指导和信息流：科学的核心将实现程序、信息流和解释框架的标准化， 通过共同的质量保证、数据生成和解释标准，加强各个项目取得成功的基础设施。通过这种方式，调查人员从所有项目产生的综合专门知识中受益。最重要的是，通过使用一个共同的网站访问组织学核心，信息流将得到改善，该网站整合了各个研究者的努力，沿着 共同的主题。4)加强基础设施：COBRE的长期目标，即通过内布拉斯加州的神经感觉发育中心在一个领域建立足够数量的研究人员，也将由核心设施提供服务。一个专门的组织学核心设施的可用性将提高COBRE研究者的竞争力，以获得校外资金，保留资助的研究者，并吸引和招募新的研究者进入神经感觉发育中心。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Histology Core has the mission to serve the investigators of the COBRE Program with their needs in specialized morphological and histological analysis of neurosensory development and relevant mousephenotypes. A Core Facility for histology offers several advantages to the COBRE investigators and the COBRE Program: 1) Enrichment of Resources: The establishment of the Core Facility with expert personnel will provide the individual investigators with a multitude of services, equipment resources and technical expertise that is not readily available within their individual laboratories. This will significantly broaden the depth of the individual research projects and support the development of state-of-the-art and technologically comprehensive research programs within the individual junior investigators' laboratories. 2) Efficiency of Personnel and Cost Management: The concentration of such resources within the Core allows for better efficiency and standardization in the usage of typically costly reagents, such as for example, specialized antibodies. Furthermore, the involvement of the highly trained and experienced Director of Phenotyping Services at UNMC, Ms. M. Anita Jennings, will reduce the need for each PI to allocate their personnel to methodologies that require extensive training and time in order to be proficiently carried out. In addition, the use of common reagents will better allow investigators from the different laboratories to compare and interpret results. 3) Quality Assurance, Mentoring and Information Flow: Scientifically, the Core will enable a standardization of procedures, of flow of information, and of frameworks for interpretation that will greatly enhance the infrastructure for success of individual projects through common quality assurance, data generation and interpretation standards. In this way, investigators benefit from the combined expertise generated through all of the projects. Most importantly, information flow will be improved through the use of a common Website for access to the Histology Core that integrates the efforts of individual investigators along common themes. 4) Enhancement of Infrastructure: The long-term objective of the COBRE, namely, to establish a critical mass of investigators on one area through the Center for Neurosensory Development in Nebraska, will also be served by the Core Facility. The availability of a specialized Histology Core Facility will increase the competitiveness of COBRE investigators for extramural funding, serve in retention of funded investigators, and attract and recruit new investigators into the Center for Neurosensory Development.