IDENTIFICATION/CHARACTERIZATION OF VIRUS-INDUCED CELL DEATH GENES IN NICOTIANA

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 植物病毒在寄主上引起的特征性症状是病毒与寄主基因产物相互作用的结果。虽然已被证明是比较容易确定的植物病毒基因负责症状的发展或宿主范围的决定，这些基因产物引起特定的反应或影响主机范围的机制仍有待充分了解。我的研究试图表征负责烟草花叶病毒引起的烟草过敏反应和烟草脆裂病毒诱导的烟草系统性细胞死亡的病毒和植物基因。 从这些宿主-病原体系统获得的信息将提供对这些病毒如何引起不同的细胞死亡反应的更好理解，并对植物病毒诱导症状的机制提供新的见解。此外，该项目使本科生接触分子生物学，分子植物病理学以及生物技术在植物保护中的有益用途。 科尔博士接待了一位来自蒙大拿州的研究员。2010年夏天，马蒂学院。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The characteristic symptoms induced by a plant virus on its host result from the interactions between viral and host gene products. While it has been proven to be relatively easy to identify plant virus genes responsible for symptom development or for host range determination, the mechanisms by which these gene products elicit specific responses or influence host range remain to be fully understood. My research attempts to characterize the viral and plant genes responsible for the hypersensitive response elicited in Nicotiana gossei by Tobacco mosaic virus and the systemic cell death induced in Nicotiana excelsior by Tobacco rattle virus. The information gained from these host-pathogen systems will provide a greater understanding of how these viruses elicit different cell death responses and new insights into the mechanisms of plant virus-induced symptoms. Furthermore, this project exposes undergraduate students to the areas of molecular biology, molecular plant pathology, and the beneficial uses of biotechnology in plant protection. Dr. Cole hosted a fellow from Mt. Marty College during the summer of 2010.