Protein Structure and Function

描述(由申请人提供)：本提案请求支持继续在堪萨斯大学建立蛋白质结构和功能生物医学研究卓越中心(Cobre-PSF)。我们的中心成立于2002年10月，包括来自另外三所堪萨斯大学的参与者。五年后，我们的所有初步目标都已实现，而且在大多数情况下，都远远超过了这些目标。我们已使9名初级调查人员获得独立的R01支持，通过替换和试点项目赠款招聘和支持了总共15名额外的初级调查人员，举办了6次科学研讨会和3次赠款撰写研讨会，并鼓励了多项研究合作。我们还改建了6000多平方米。英尺的空间，建造了一个新的17,500平方米。成立了一个致力于生物核磁共振的新核心，并制定了将Cobre-PSF朝着自给自足的研究中心发展的计划。我们的研究人员已经发表了226多篇同行评议的手稿，并获得了69项研究拨款，总额超过2200万美元。 在续期期间，我们对中心的总体目标是： (一)招收、辅导和加快优秀青年科学家的职业发展 2.提升我们现有蛋白质生产核心实验室(核心B)的能力 3.加强我们现有蛋白质结构实验室(核心C)的能力 4.建设专门从事蛋白质核磁共振研究的生物核磁共振核心实验室(核心D) 5.通过研究会议、研讨会、赠款申请编写讲习班和科学讲习班相结合的方式，加速中心所有参与者的专业和科学成长。 我们的长期目标是培养一批成功、独立但合作的研究人员，专注于健康和疾病中的蛋白质结构和功能，通过这些研究，Cobre-PSF将成为未来自给自足的企业。 莱伊声明：基因组学的巨大进步为确定最终导致正常细胞功能和疾病状态下的功能障碍的细胞蛋白铺平了道路。治疗干预措施的开发始于了解与疾病有关的蛋白质，这需要在细胞蛋白质研究方面拥有杰出专业知识的科学家。

DESCRIPTION (provided by applicant): This proposal requests support to continue development of a Center of Biomedical Research Excellence in Protein Structure and Function (COBRE-PSF) at the University of Kansas. Our Center was established in October 2002, and includes participants from three additional Kansas Universities. After five years all of our initial goals have been met and, in most cases, surpassed by a wide margin. We have graduated nine junior investigators to independent R01 support, recruited and supported a total of 15 additional junior investigators through replacement and pilot project grants, held six scientific and three grant-writing workshops, and inspired multiple research collaborations. We also remodeled over 6000 sq. feet of space, built a new 17,500 sq. foot Structural Biology Center, inaugurated a new Core dedicated to Bio-NMR, and enacted plans to move COBRE-PSF toward a self-sustaining research center. Our investigators have published over 226 peer-reviewed manuscripts and have received 69 research grants totaling more than $22 million. For the renewal period, our overall Aims for the Center are: 1. To recruit, mentor, and accelerate the career development of outstanding junior scientists 2. To enhance the capabilities of our existing Protein Production Core Laboratory (Core B) 3. To enhance the capabilities of our existing Protein Structure Laboratory (Core C) 4. To build a Bio-NMR Core Laboratory dedicated to Protein NMR studies (Core D) 5. To accelerate the professional and scientific growth of all Center participants through a combination of research meetings, seminars, grant application writing workshops, and scientific workshops. Our long-term goal is to attain a critical mass of successful, independent but collaborative investigators, focused on protein structure and function in health and disease, through which COBRE-PSF will become a self-sustaining enterprise into the future. Lay statement: Great advances in genomics paved the way for identifying the cellular proteins that are ultimately responsible for normal cell functioning and for the dysfunction underlying disease states. Development of therapeutic interventions begins with understanding the proteins involved in diseases, and this requires scientists with outstanding expertise in the study of cellular proteins.