3D RADIAL PIPELINE FOR RECONSTRUCTION OF CLINICAL 129XE IMAGES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们目前正在进行超极化129的临床成像。历史上，我们使用在扫描仪上重建的多切片GRE序列。然而，我们现在越来越有兴趣使用径向采集和重建这项工作。因此，我们越来越依赖于由CIVM工作人员维护的数据重建和图像存档管道。我们正在进行的项目将致力于产生各向同性的129氚通气图像以及溶解在肺血液和组织中的129氚的图像。还正在进行脉冲序列开发，以便在单次屏气期间同时采集这两种图像。这项工作利用了CIVM基础设施，但不需要进一步的支持。编写本项目表是为了记录CIVM基础设施的使用情况，并确保项目代码可用于重建和存档氙气图像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are currently conducting clinical imaging of hyperpolarized 129Xe. Historically we have used multi-slice GRE sequences that reconstruct on the scanner. However, we are now becoming increasingly interested in using radial acquisition and reconstruction for this work. Hence, we are becoming increasingly reliant on the data reconstruction and image archiving pipeline maintained by the CIVM staff. Our ongoing program will be working to produce isotropic 129Xe ventilation images as well as images of 129Xe dissolved in pulmonary blood and tissues. On-going pulse sequence development is also being done to acquire both of these images simultaneously during a single breath hold. This work makes use of the CIVM infrastructure, but should require no further support. This project form is being written to document usage of the CIVM infrastructure and to ensure that a project code is available for reconstructing and archiving xenon images.