NEW AND IMPROVED ENDOGENOUS MAGNETIZATION CONTRAST IN MRI

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 磁共振成像技术如磁化转移（MT）、化学交换饱和转移（CEST）和磁化交换（ME）等正在发展，以探索大分子的信息 以及由于超短T2或非常低的浓度而不能直接成像的代谢物。Z谱数据被用来研究这些现象。Z-谱曲线是体水直接饱和（DS）、MT、CEST、ME效应的混合响应;然而，单个组分的量化是必要的，具有挑战性的，并且一直是研究的热点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. MRI techniques like magnetization transfer (MT), chemical exchange saturation transfer (CEST) and magnetization exchange (ME) are being developed to explore the information about macromolecules and metabolites which cannot be imaged directly due to either ultra-short T2 or very low concentration. Z-spectrum data is used to study these phenomenons. Z-spectrum curve is mixed response of direct saturation (DS) of bulk water, MT, CEST, ME effects; quantification of individual components is essential however, challenging and has been a hot topic of research.